TY - JOUR
T1 - Directed cell invasion and migration during metastasis
AU - Bravo-Cordero, Jose Javier
AU - Hodgson, Louis
AU - Condeelis, John
N1 - Funding Information:
The authors would like to thank members of the Condeelis and Hodgson laboratories for helpful discussions. We thank Current Biology Journal for granting copyright permission to adapt Figure 4 bottom part (from Figure 1 of MacGrath, S.M., and Koleske, A.J (2011)). We thank especially Dr Minna Roh for her critical comments and suggestions for this manuscript and Dr. Robert Eddy for generously provide models for Figure 2. The authors apologize to those whose work is not cited owing to space limitations. The authors’ research is funded by grants: GM093121 (LH, JJB-C), ‘Sinsheimer Foundation Young Investigator Award’ (LH) and CA150344 (JC and JJB-C).
PY - 2012/4
Y1 - 2012/4
N2 - Metastasis requires tumor cell dissemination to different organs from the primary tumor. Dissemination is a complex cell motility phenomenon that requires the molecular coordination of the protrusion, chemotaxis, invasion and contractility activities of tumor cells to achieve directed cell migration. Recent studies of the spatial and temporal activities of the small GTPases have begun to elucidate how this coordination is achieved. The direct visualization of the pathways involved in actin polymerization, invasion and directed migration in dissemination competent tumor cells will help identify the molecular basis of dissemination and allow the design and testing of more specific and selective drugs to block metastasis.
AB - Metastasis requires tumor cell dissemination to different organs from the primary tumor. Dissemination is a complex cell motility phenomenon that requires the molecular coordination of the protrusion, chemotaxis, invasion and contractility activities of tumor cells to achieve directed cell migration. Recent studies of the spatial and temporal activities of the small GTPases have begun to elucidate how this coordination is achieved. The direct visualization of the pathways involved in actin polymerization, invasion and directed migration in dissemination competent tumor cells will help identify the molecular basis of dissemination and allow the design and testing of more specific and selective drugs to block metastasis.
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U2 - 10.1016/j.ceb.2011.12.004
DO - 10.1016/j.ceb.2011.12.004
M3 - Review article
C2 - 22209238
AN - SCOPUS:84861804698
SN - 0955-0674
VL - 24
SP - 277
EP - 283
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 2
ER -