Abstract
The glycosyl epitope dimeric Lea (Lea-on-Le a), defined by mouse monoclonal antibody NCC-ST-421, was identified previously as tumor-associated antigen, expressed highly in various human cancer tissues and cell lines derived therefrom, but with minimal expression in various normal tissues. In the present study, we observed clearly higher expression of this epitope, defined by ST421, in ß-haptoglobin (ß-Hap) from sera of patients with colorectal cancer, compared to normal, healthy subjects or patients with chronic inflammatory processes (Crohn's disease, ulcerative colitis).
Original language | English (US) |
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Pages (from-to) | 1291-1297 |
Number of pages | 7 |
Journal | International journal of oncology |
Volume | 36 |
Issue number | 5 |
DOIs | |
State | Published - May 2010 |
Externally published | Yes |
Keywords
- Colon cancer
- Dimeric Le
- Haptoglobin
- Lectin blotting
- O-linked glycan
ASJC Scopus subject areas
- Oncology
- Cancer Research