Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones

Padmini Salgame; John S. Abrams; Caol Clayberger; Harris Goldstein; Jacinto Convit; Robert L. Modlin; Barry R. Bloom

doi:10.1126/science.1681588

Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones

Padmini Salgame, John S. Abrams, Caol Clayberger, Harris Goldstein, Jacinto Convit, Robert L. Modlin, Barry R. Bloom

Pediatrics

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Abstract

Functional subsets of human T cells were delineated by analyzing patterns of lymphokines produced by clones from individuals with leprosy and by T cell clones of known function. CD4 clones from individuals with strong cell-mediated immunity produced predominantly interferon-γ, whereas those clones that enhanced antibody formation produced interleukin-4. CD8 cytotoxic T cells secreted interferon-γ. Interleukin-4 was produced by CD8 T suppressor clones from immunologically unresponsive individuals with leprosy and was found to be necessary for suppression in vitro. Both the classic reciprocal relation between antibody formation and cell-mediated immunity and resistance or susceptibility to certain infections may be explained by T cell subsets differing in patterns of lymphokine production.

Original language	English (US)
Pages (from-to)	279-282
Number of pages	4
Journal	Science
Volume	254
Issue number	5029
DOIs	https://doi.org/10.1126/science.1681588
State	Published - 1991

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abstract = "Functional subsets of human T cells were delineated by analyzing patterns of lymphokines produced by clones from individuals with leprosy and by T cell clones of known function. CD4 clones from individuals with strong cell-mediated immunity produced predominantly interferon-γ, whereas those clones that enhanced antibody formation produced interleukin-4. CD8 cytotoxic T cells secreted interferon-γ. Interleukin-4 was produced by CD8 T suppressor clones from immunologically unresponsive individuals with leprosy and was found to be necessary for suppression in vitro. Both the classic reciprocal relation between antibody formation and cell-mediated immunity and resistance or susceptibility to certain infections may be explained by T cell subsets differing in patterns of lymphokine production.",

author = "Padmini Salgame and Abrams, {John S.} and Caol Clayberger and Harris Goldstein and Jacinto Convit and Modlin, {Robert L.} and Bloom, {Barry R.}",

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T1 - Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones

AU - Salgame, Padmini

AU - Abrams, John S.

AU - Clayberger, Caol

AU - Goldstein, Harris

AU - Convit, Jacinto

AU - Modlin, Robert L.

AU - Bloom, Barry R.

PY - 1991

Y1 - 1991

N2 - Functional subsets of human T cells were delineated by analyzing patterns of lymphokines produced by clones from individuals with leprosy and by T cell clones of known function. CD4 clones from individuals with strong cell-mediated immunity produced predominantly interferon-γ, whereas those clones that enhanced antibody formation produced interleukin-4. CD8 cytotoxic T cells secreted interferon-γ. Interleukin-4 was produced by CD8 T suppressor clones from immunologically unresponsive individuals with leprosy and was found to be necessary for suppression in vitro. Both the classic reciprocal relation between antibody formation and cell-mediated immunity and resistance or susceptibility to certain infections may be explained by T cell subsets differing in patterns of lymphokine production.

AB - Functional subsets of human T cells were delineated by analyzing patterns of lymphokines produced by clones from individuals with leprosy and by T cell clones of known function. CD4 clones from individuals with strong cell-mediated immunity produced predominantly interferon-γ, whereas those clones that enhanced antibody formation produced interleukin-4. CD8 cytotoxic T cells secreted interferon-γ. Interleukin-4 was produced by CD8 T suppressor clones from immunologically unresponsive individuals with leprosy and was found to be necessary for suppression in vitro. Both the classic reciprocal relation between antibody formation and cell-mediated immunity and resistance or susceptibility to certain infections may be explained by T cell subsets differing in patterns of lymphokine production.

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Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones

Abstract

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