TY - JOUR
T1 - Dietary factors and fibroblast growth factor-23 levels in young adults with African ancestry
AU - Kosk, Dominique
AU - Kramer, Holly
AU - Luke, Amy
AU - Camacho, Pauline
AU - Bovet, Pascal
AU - Rhule, Jacob Plange
AU - Forrester, Terrence
AU - Wolf, Myles
AU - Sempos, Chris
AU - Melamed, Michal L.
AU - Dugas, Lara R.
AU - Cooper, Richard
AU - Durazo-Arvizu, Ramon
N1 - Funding Information:
American Public Health Association Meeting October 2015, Chicago IL (DK). The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institutes of Health or the US Department of Health and Human Services. This study was supported in part by funding from the National Institutes of Health 1R01DK90360-1A1 (RD), 5R01DK080763-04 (AL), and by Loyola University Chicago–Intramural Award LU#204006.
Funding Information:
Data were presented in poster form at the American Public Health Association Meeting October 2015, Chicago IL (DK). The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institutes of Health or the US Department of Health and Human Services. This study was supported in part by funding from the National Institutes of Health 1R01DK90360-1A1 (RD), 5R01DK080763-04 (AL), and by Loyola University Chicago?Intramural Award LU#204006. The authors have no conflicts of interest to disclose.
Publisher Copyright:
© 2016, The Japanese Society for Bone and Mineral Research and Springer Japan.
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Fibroblast growth factor-23 (FGF23), a phosphaturic hormone secreted mainly by osteocytes, maintains serum phosphate levels within a tight range by promoting phosphaturia. Previous studies have mainly focused on the link between FGF23 levels and dietary intake of phosphate, but other dietary factors may also influence FGF23 levels. This cross-sectional study pooled three populations of young adults with African ancestry (452 in Chicago, IL, USA; 477 in Victoria, Seychelles; and 482 in Kumasi, Ghana) with estimated glomerular filtration rate >80 ml/min/1.73 m2 to examine the association of dietary factors based on two 24-h recalls with FGF23 levels measured using a C-terminal assay. Linear regression was used to examine the association between log-transformed FGF23 levels and quartiles of calorie-adjusted dietary factors with adjustment for covariates. In the pooled sample of 1411 study participants, the mean age was 35.2 (6.2) years and 45.3% were male. Median plasma C-terminal FGF23 values in relative units (RU)/ml were 59.5 [interquartile range (IQR) 44.1, 85.3] in the USA, 43.2 (IQR 33.1, 57.9) in Seychelles, and 34.0 (IQR 25.2, 50.4) in Ghana. With adjustment for covariates, increasing quartiles of calcium and animal protein and decreasing quartiles of vegetable protein, fiber, and magnesium intake were associated with significantly higher FGF23 levels compared to the lowest quartile. After further adjustment for dietary factors, significant trends in FGF23 levels were noted only for quartiles of calcium, fiber, and magnesium intake (P < 0.001). Dietary factors other than phosphate are associated with FGF23 levels in young adults.
AB - Fibroblast growth factor-23 (FGF23), a phosphaturic hormone secreted mainly by osteocytes, maintains serum phosphate levels within a tight range by promoting phosphaturia. Previous studies have mainly focused on the link between FGF23 levels and dietary intake of phosphate, but other dietary factors may also influence FGF23 levels. This cross-sectional study pooled three populations of young adults with African ancestry (452 in Chicago, IL, USA; 477 in Victoria, Seychelles; and 482 in Kumasi, Ghana) with estimated glomerular filtration rate >80 ml/min/1.73 m2 to examine the association of dietary factors based on two 24-h recalls with FGF23 levels measured using a C-terminal assay. Linear regression was used to examine the association between log-transformed FGF23 levels and quartiles of calorie-adjusted dietary factors with adjustment for covariates. In the pooled sample of 1411 study participants, the mean age was 35.2 (6.2) years and 45.3% were male. Median plasma C-terminal FGF23 values in relative units (RU)/ml were 59.5 [interquartile range (IQR) 44.1, 85.3] in the USA, 43.2 (IQR 33.1, 57.9) in Seychelles, and 34.0 (IQR 25.2, 50.4) in Ghana. With adjustment for covariates, increasing quartiles of calcium and animal protein and decreasing quartiles of vegetable protein, fiber, and magnesium intake were associated with significantly higher FGF23 levels compared to the lowest quartile. After further adjustment for dietary factors, significant trends in FGF23 levels were noted only for quartiles of calcium, fiber, and magnesium intake (P < 0.001). Dietary factors other than phosphate are associated with FGF23 levels in young adults.
KW - Calcium intake
KW - FGF23
KW - Fibroblast growth factor 23
KW - Phosphate intake
KW - Vitamin D
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UR - http://www.scopus.com/inward/citedby.url?scp=85004098367&partnerID=8YFLogxK
U2 - 10.1007/s00774-016-0804-5
DO - 10.1007/s00774-016-0804-5
M3 - Article
C2 - 27942978
AN - SCOPUS:85004098367
SN - 0914-8779
VL - 35
SP - 666
EP - 674
JO - Journal of Bone and Mineral Metabolism
JF - Journal of Bone and Mineral Metabolism
IS - 6
ER -
