Developmental Neurotoxicity of Lead

Samuel Caito, Michael Aschner

Research output: Chapter in Book/Report/Conference proceedingChapter

61 Scopus citations


Lead exposure is a major concern for the developing nervous system. Environmental exposures to lead, predominantly from contaminated water or lead paint chips, account for the majority of exposures to children. In utero and early life exposures to lead have been associated with lower IQ, antisocial and delinquent behaviors, and attention-deficit hyperactivity disorder. In this review, we will discuss sources of developmental lead exposure and mechanisms of lead neurotoxicity. We will highlight both human epidemiological studies showing associations between lead exposure and behavioral abnormalities as well as experimental data from animal studies. Finally, we will discuss the effects of lead on neurological endpoint past childhood, namely, development of Alzheimer’s disease in old age.

Original languageEnglish (US)
Title of host publicationAdvances in Neurobiology
PublisherSpringer New York LLC
Number of pages10
StatePublished - 2017

Publication series

NameAdvances in Neurobiology
ISSN (Print)2190-5215


  • Air quality criteria
  • Alzheimer’s disease
  • Behavioral impairments
  • Encephalopathy
  • Metalloproteins
  • Permissible exposure limit (PEL)

ASJC Scopus subject areas

  • Biochemistry
  • Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience


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