Developmental Mechanisms of Aortic Valve Malformation and Disease

Bingruo Wu, Yidong Wang, Feng Xiao, Jonathan T. Butcher, Katherine E. Yutzey, Bin Zhou

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations


Normal aortic valves are composed of valve endothelial cells (VECs) and valve interstitial cells (VICs). VICs are the major cell population and have distinct embryonic origins in the endocardium and cardiac neural crest cells. Cell signaling between the VECs and VICs plays critical roles in aortic valve morphogenesis. Disruption of major cell signaling pathways results in aortic valve malformations, including bicuspid aortic valve (BAV). BAV is a common congenital heart valve disease that may lead to calcific aortic valve disease (CAVD), but there is currently no effective medical treatment for this beyond surgical replacement. Mouse and human studies have identified causative gene mutations for BAV and CAVD via disrupted VEC to VIC signaling. Future studies on the developmental signaling mechanisms underlying aortic valve malformations and the pathogenesis of CAVD using genetically modified mouse models and patient-induced pluripotent stem cells may identify new effective therapeutic targets for the disease.

Original languageEnglish (US)
Pages (from-to)21-41
Number of pages21
JournalAnnual review of physiology
StatePublished - Feb 10 2017


  • Animal model
  • Bicuspid aortic valve
  • Cell signaling
  • Heart valve development
  • Valve endocardial cell
  • Valve interstitial cell

ASJC Scopus subject areas

  • Physiology


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