Abstract
Mice deficient in carbonic anhydrase II (CA II) were tested along with their normal littermates for susceptibility to seizures induced by flurothyl and loud sound at ages 10-180 days. In the flurothyl seizure model, CA II-deficient mice displayed increased resistance to clonic seizures from 32 to 90 days of age, whereas tonic-clonic seizures were suppressed at all ages. The mortality of CA II-deficient mice was significantly decreased at ages 19-40 days. The incidence of sound-induced seizures was very low and no difference between CA II-deficient and normal mice was found. The anticonvulsant effect of CA II deficiency appears to be dependent on seizure model and seizure type and to have age-specific characteristics.
Original language | English (US) |
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Pages (from-to) | 321-324 |
Number of pages | 4 |
Journal | Developmental Brain Research |
Volume | 72 |
Issue number | 2 |
DOIs | |
State | Published - Apr 16 1993 |
Keywords
- Carbonic anhydrase deficiency
- Development
- Flurothyl
- Mouse
- Seizure
ASJC Scopus subject areas
- Developmental Neuroscience
- Developmental Biology