Development and preliminary experience with an ease of Extractability Rating System for prescription opioids

N. P. Katz; D. C. Buse; S. H. Budman; S. Wing Venuti; K. C. Fernandez; C. Benoit; R. Bianchi; D. Cooper; D. R. Jasinski; D. E. Smith; S. F. Butler

doi:10.1080/03639040500529093

Development and preliminary experience with an ease of Extractability Rating System for prescription opioids

N. P. Katz, D. C. Buse, S. H. Budman, S. Wing Venuti, K. C. Fernandez, C. Benoit, R. Bianchi, D. Cooper, D. R. Jasinski, D. E. Smith, S. F. Butler

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

One important factor in the abuse potential of an opioid product is the ease with which active drug can be extracted. There are currently no standards for testing or reporting extractability. This article describes the development of an Extractability Rating System for use by the pharmaceutical industry and regulators. Despite several limitations, this effort serves as a call for standardized testing and reporting so that products can be accurately rated, and should help establish goals for drug developers who wish to develop "abuse-resistant" opioid products.

Original language	English (US)
Pages (from-to)	727-746
Number of pages	20
Journal	Drug Development and Industrial Pharmacy
Volume	32
Issue number	6
DOIs	https://doi.org/10.1080/03639040500529093
State	Published - Jun 1 2006
Externally published	Yes

Keywords

Controlled Substances Act
Extractability
Narcotic
Opioid
Substance abuse

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/03639040500529093

Cite this

Katz, N. P., Buse, D. C., Budman, S. H., Wing Venuti, S., Fernandez, K. C., Benoit, C., Bianchi, R., Cooper, D., Jasinski, D. R., Smith, D. E., & Butler, S. F. (2006). Development and preliminary experience with an ease of Extractability Rating System for prescription opioids. Drug Development and Industrial Pharmacy, 32(6), 727-746. https://doi.org/10.1080/03639040500529093

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abstract = "One important factor in the abuse potential of an opioid product is the ease with which active drug can be extracted. There are currently no standards for testing or reporting extractability. This article describes the development of an Extractability Rating System for use by the pharmaceutical industry and regulators. Despite several limitations, this effort serves as a call for standardized testing and reporting so that products can be accurately rated, and should help establish goals for drug developers who wish to develop {"}abuse-resistant{"} opioid products.",

keywords = "Controlled Substances Act, Extractability, Narcotic, Opioid, Substance abuse",

author = "Katz, {N. P.} and Buse, {D. C.} and Budman, {S. H.} and {Wing Venuti}, S. and Fernandez, {K. C.} and C. Benoit and R. Bianchi and D. Cooper and Jasinski, {D. R.} and Smith, {D. E.} and Butler, {S. F.}",

note = "Funding Information: We gratefully acknowledge funding support of Janssen Pharmaceutical Incorporated. In addition we would like to acknowledge Wilmer Kiser, BA, Audra Stinchcomb, Ph.D., and Surya Vangapandu, Ph.D., for their participation in the usability testing of our rating tools.",

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doi = "10.1080/03639040500529093",

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AU - Katz, N. P.

AU - Buse, D. C.

AU - Budman, S. H.

AU - Wing Venuti, S.

AU - Fernandez, K. C.

AU - Benoit, C.

AU - Bianchi, R.

AU - Cooper, D.

AU - Jasinski, D. R.

AU - Smith, D. E.

AU - Butler, S. F.

N1 - Funding Information: We gratefully acknowledge funding support of Janssen Pharmaceutical Incorporated. In addition we would like to acknowledge Wilmer Kiser, BA, Audra Stinchcomb, Ph.D., and Surya Vangapandu, Ph.D., for their participation in the usability testing of our rating tools.

PY - 2006/6/1

Y1 - 2006/6/1

N2 - One important factor in the abuse potential of an opioid product is the ease with which active drug can be extracted. There are currently no standards for testing or reporting extractability. This article describes the development of an Extractability Rating System for use by the pharmaceutical industry and regulators. Despite several limitations, this effort serves as a call for standardized testing and reporting so that products can be accurately rated, and should help establish goals for drug developers who wish to develop "abuse-resistant" opioid products.

AB - One important factor in the abuse potential of an opioid product is the ease with which active drug can be extracted. There are currently no standards for testing or reporting extractability. This article describes the development of an Extractability Rating System for use by the pharmaceutical industry and regulators. Despite several limitations, this effort serves as a call for standardized testing and reporting so that products can be accurately rated, and should help establish goals for drug developers who wish to develop "abuse-resistant" opioid products.

KW - Controlled Substances Act

KW - Extractability

KW - Narcotic

KW - Opioid

KW - Substance abuse

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Development and preliminary experience with an ease of Extractability Rating System for prescription opioids

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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