Deactivation of LVAD support for myocardial recovery—surgical perspectives

Ian Nickel; Evgenij Potapov; Benjamin Sun; Daniel Zimpfer; Antigone Koliopoulou; Iki Adachi; Anelechi Anyanwu; Volkmar Falk; Pavan Atluri; Gloria Faerber; Daniel Goldstein; Leora Yarboro; Mark S. Slaughter; Carmelo Milano; Masaki Tsukashita; David A. D'Alessandro; Scott Silvestry; Hristo Kirov; Swaroop Bommareddi; Pia Lanmüller; Torsten Doenst; Craig H. Selzman

doi:10.1016/j.healun.2024.05.005

Deactivation of LVAD support for myocardial recovery—surgical perspectives

Ian Nickel, Evgenij Potapov, Benjamin Sun, Daniel Zimpfer, Antigone Koliopoulou, Iki Adachi, Anelechi Anyanwu, Volkmar Falk, Pavan Atluri, Gloria Faerber, Daniel Goldstein, Leora Yarboro, Mark S. Slaughter, Carmelo Milano, Masaki Tsukashita, David A. D'Alessandro, Scott Silvestry, Hristo Kirov, Swaroop Bommareddi, Pia LanmüllerTorsten Doenst, Craig H. Selzman

Montefiore Einstein Center for Heart and Vascular Care

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Left ventricular assist devices (LVADs) are excellent therapies for advanced heart failure patients either bridged to transplant or for lifetime use. LVADs also allow for reverse remodeling of the failing heart that is often associated with functional improvement. Indeed, growing enthusiasm exists to better understand this population of patients, whereby the LVAD is used as an adjunct to mediate myocardial recovery. When patients achieve benchmarks suggesting that they no longer need LVAD support, questions related to the discontinuation of LVAD therapy become front and center. The purpose of this review is to provide a surgical perspective on the practical and technical issues surrounding LVAD deactivation.

Original language	English (US)
Pages (from-to)	1489-1500
Number of pages	12
Journal	Journal of Heart and Lung Transplantation
Volume	43
Issue number	9
DOIs	https://doi.org/10.1016/j.healun.2024.05.005
State	Published - Sep 2024

Keywords

decommissioning
explant
heart failure
mechanical circulatory support
myocardial recovery
VAD

ASJC Scopus subject areas

Surgery
Pulmonary and Respiratory Medicine
Cardiology and Cardiovascular Medicine
Transplantation

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10.1016/j.healun.2024.05.005

Cite this

Nickel, I., Potapov, E., Sun, B., Zimpfer, D., Koliopoulou, A., Adachi, I., Anyanwu, A., Falk, V., Atluri, P., Faerber, G., Goldstein, D., Yarboro, L., Slaughter, M. S., Milano, C., Tsukashita, M., D'Alessandro, D. A., Silvestry, S., Kirov, H., Bommareddi, S., ... Selzman, C. H. (2024). Deactivation of LVAD support for myocardial recovery—surgical perspectives. Journal of Heart and Lung Transplantation, 43(9), 1489-1500. https://doi.org/10.1016/j.healun.2024.05.005

Nickel, I, Potapov, E, Sun, B, Zimpfer, D, Koliopoulou, A, Adachi, I, Anyanwu, A, Falk, V, Atluri, P, Faerber, G, Goldstein, D, Yarboro, L, Slaughter, MS, Milano, C, Tsukashita, M, D'Alessandro, DA, Silvestry, S, Kirov, H, Bommareddi, S, Lanmüller, P, Doenst, T & Selzman, CH 2024, 'Deactivation of LVAD support for myocardial recovery—surgical perspectives', Journal of Heart and Lung Transplantation, vol. 43, no. 9, pp. 1489-1500. https://doi.org/10.1016/j.healun.2024.05.005

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title = "Deactivation of LVAD support for myocardial recovery—surgical perspectives",

abstract = "Left ventricular assist devices (LVADs) are excellent therapies for advanced heart failure patients either bridged to transplant or for lifetime use. LVADs also allow for reverse remodeling of the failing heart that is often associated with functional improvement. Indeed, growing enthusiasm exists to better understand this population of patients, whereby the LVAD is used as an adjunct to mediate myocardial recovery. When patients achieve benchmarks suggesting that they no longer need LVAD support, questions related to the discontinuation of LVAD therapy become front and center. The purpose of this review is to provide a surgical perspective on the practical and technical issues surrounding LVAD deactivation.",

keywords = "decommissioning, explant, heart failure, mechanical circulatory support, myocardial recovery, VAD",

author = "Ian Nickel and Evgenij Potapov and Benjamin Sun and Daniel Zimpfer and Antigone Koliopoulou and Iki Adachi and Anelechi Anyanwu and Volkmar Falk and Pavan Atluri and Gloria Faerber and Daniel Goldstein and Leora Yarboro and Slaughter, {Mark S.} and Carmelo Milano and Masaki Tsukashita and D'Alessandro, {David A.} and Scott Silvestry and Hristo Kirov and Swaroop Bommareddi and Pia Lanm{\"u}ller and Torsten Doenst and Selzman, {Craig H.}",

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doi = "10.1016/j.healun.2024.05.005",

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AU - Potapov, Evgenij

AU - Sun, Benjamin

AU - Zimpfer, Daniel

AU - Koliopoulou, Antigone

AU - Adachi, Iki

AU - Anyanwu, Anelechi

AU - Falk, Volkmar

AU - Atluri, Pavan

AU - Faerber, Gloria

AU - Goldstein, Daniel

AU - Yarboro, Leora

AU - Slaughter, Mark S.

AU - Milano, Carmelo

AU - Tsukashita, Masaki

AU - D'Alessandro, David A.

AU - Silvestry, Scott

AU - Kirov, Hristo

AU - Bommareddi, Swaroop

AU - Lanmüller, Pia

AU - Doenst, Torsten

AU - Selzman, Craig H.

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N2 - Left ventricular assist devices (LVADs) are excellent therapies for advanced heart failure patients either bridged to transplant or for lifetime use. LVADs also allow for reverse remodeling of the failing heart that is often associated with functional improvement. Indeed, growing enthusiasm exists to better understand this population of patients, whereby the LVAD is used as an adjunct to mediate myocardial recovery. When patients achieve benchmarks suggesting that they no longer need LVAD support, questions related to the discontinuation of LVAD therapy become front and center. The purpose of this review is to provide a surgical perspective on the practical and technical issues surrounding LVAD deactivation.

AB - Left ventricular assist devices (LVADs) are excellent therapies for advanced heart failure patients either bridged to transplant or for lifetime use. LVADs also allow for reverse remodeling of the failing heart that is often associated with functional improvement. Indeed, growing enthusiasm exists to better understand this population of patients, whereby the LVAD is used as an adjunct to mediate myocardial recovery. When patients achieve benchmarks suggesting that they no longer need LVAD support, questions related to the discontinuation of LVAD therapy become front and center. The purpose of this review is to provide a surgical perspective on the practical and technical issues surrounding LVAD deactivation.

KW - decommissioning

KW - explant

KW - heart failure

KW - mechanical circulatory support

KW - myocardial recovery

KW - VAD

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JO - Journal of Heart and Lung Transplantation

JF - Journal of Heart and Lung Transplantation

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Deactivation of LVAD support for myocardial recovery—surgical perspectives

Abstract

Keywords

ASJC Scopus subject areas

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