D-lactic acidosis mediated neuronal encephalopathy in acute lymphoblastic leukemia patient: An under diagnosis

Damodara Rao Mendu; Martin Fleisher; Samuel I. McCash; Melissa S. Pessin; Lakshmi V. Ramanathan

doi:10.1016/j.cca.2014.12.025

D-lactic acidosis mediated neuronal encephalopathy in acute lymphoblastic leukemia patient: An under diagnosis

Damodara Rao Mendu
, Martin Fleisher
, Samuel I. McCash
, Melissa S. Pessin
, Lakshmi V. Ramanathan

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Background: D-lactic acidosis, also referred as D-lactate encephalopathy, has been reported in patients with short bowl syndrome (SBS). Case report: The neurologic symptoms include altered mental status, slurred speech, and ataxia. Onset of neurological symptoms is accompanied by metabolic acidosis and high anion gap. We present here a case of D-lactic acidosis in a patient with acute lymphoblastic leukemia (ALL) who developed severe neurological symptoms and metabolic acidosis due to vancomycin-resistant enterococci (VRE) infection, and elevated D-lactic acid.

Original language	English (US)
Pages (from-to)	90-91
Number of pages	2
Journal	Clinica Chimica Acta
Volume	441
DOIs	https://doi.org/10.1016/j.cca.2014.12.025
State	Published - Feb 4 2015
Externally published	Yes

Keywords

D-lactic acid
Hematological malignancy
Neuropathy

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Biochemistry, medical

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10.1016/j.cca.2014.12.025

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title = "D-lactic acidosis mediated neuronal encephalopathy in acute lymphoblastic leukemia patient: An under diagnosis",

abstract = "Background: D-lactic acidosis, also referred as D-lactate encephalopathy, has been reported in patients with short bowl syndrome (SBS). Case report: The neurologic symptoms include altered mental status, slurred speech, and ataxia. Onset of neurological symptoms is accompanied by metabolic acidosis and high anion gap. We present here a case of D-lactic acidosis in a patient with acute lymphoblastic leukemia (ALL) who developed severe neurological symptoms and metabolic acidosis due to vancomycin-resistant enterococci (VRE) infection, and elevated D-lactic acid.",

keywords = "D-lactic acid, Hematological malignancy, Neuropathy",

author = "Mendu, \{Damodara Rao\} and Martin Fleisher and McCash, \{Samuel I.\} and Pessin, \{Melissa S.\} and Ramanathan, \{Lakshmi V.\}",

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year = "2015",

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doi = "10.1016/j.cca.2014.12.025",

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journal = "Clinica Chimica Acta",

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T1 - D-lactic acidosis mediated neuronal encephalopathy in acute lymphoblastic leukemia patient

T2 - An under diagnosis

AU - Mendu, Damodara Rao

AU - Fleisher, Martin

AU - McCash, Samuel I.

AU - Pessin, Melissa S.

AU - Ramanathan, Lakshmi V.

PY - 2015/2/4

Y1 - 2015/2/4

N2 - Background: D-lactic acidosis, also referred as D-lactate encephalopathy, has been reported in patients with short bowl syndrome (SBS). Case report: The neurologic symptoms include altered mental status, slurred speech, and ataxia. Onset of neurological symptoms is accompanied by metabolic acidosis and high anion gap. We present here a case of D-lactic acidosis in a patient with acute lymphoblastic leukemia (ALL) who developed severe neurological symptoms and metabolic acidosis due to vancomycin-resistant enterococci (VRE) infection, and elevated D-lactic acid.

AB - Background: D-lactic acidosis, also referred as D-lactate encephalopathy, has been reported in patients with short bowl syndrome (SBS). Case report: The neurologic symptoms include altered mental status, slurred speech, and ataxia. Onset of neurological symptoms is accompanied by metabolic acidosis and high anion gap. We present here a case of D-lactic acidosis in a patient with acute lymphoblastic leukemia (ALL) who developed severe neurological symptoms and metabolic acidosis due to vancomycin-resistant enterococci (VRE) infection, and elevated D-lactic acid.

KW - D-lactic acid

KW - Hematological malignancy

KW - Neuropathy

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DO - 10.1016/j.cca.2014.12.025

M3 - Article

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VL - 441

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EP - 91

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

ER -

D-lactic acidosis mediated neuronal encephalopathy in acute lymphoblastic leukemia patient: An under diagnosis

Abstract

Keywords

ASJC Scopus subject areas

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