Cytokines in Drosophila hematopoiesis and cellular immunity.

D. L. Bodian, S. Leung, H. Chiu, S. Govind

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Hematopoiesis is a complex, multistep process in which progenitor cells undergo distinct cellular changes of proliferation and differentiation to give rise to mature blood cells in circulation. Many of the genetic and molecular events that drive these changes have been characterized in mammals, frogs, and zebra fish, and more recently in the insect model system Drosophila melanogaster. Blood cells in Drosophila are actively involved in fighting infections and the cellular immune responses are intimately tied to the process of hematopoiesis. In this article, we briefly review the fundamental similarities in Drosophila and mammalian hematopoiesis and highlight the potential roles of four cytokines/growth factors in Drosophila hematopoiesis and cellular immunity.

Original languageEnglish (US)
Pages (from-to)27-46
Number of pages20
JournalProgress in molecular and subcellular biology
StatePublished - 2004
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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