TY - JOUR
T1 - Curcumin Combats against Organophosphate Pesticides Toxicity
T2 - A Review of the Current Evidence and Molecular Pathways
AU - Jafari-Nozad, Amir Masoud
AU - Jafari, Amirsajad
AU - Aschner, Michael
AU - Farkhondeh, Tahereh
AU - Samarghandian, Saeed
N1 - Publisher Copyright:
© 2023 Bentham Science Publishers.
PY - 2023
Y1 - 2023
N2 - Organophosphate compounds are regarded as a class of pesticides that are used in farming. Their extensive use, especially in developing countries, is a serious public health problem. Numerous studies have shown the effects of these toxins on vari-ous parts of the human and other vertebrates’ bodies, including the cardiovascular, hepa-tobiliary, renal, and reproductive systems. Curcumin is a polyphenol compound obtained from the rhizome of the Curcuma longa. Curcumin has been known as a dietary spice, food additive, and traditional medicine since many years ago. In recent decades, the medicinal characteristics, clinical aspects, and biological activity of curcumin have been extensively examined. The most examined positive characteristics of curcumin are its an-ti-inflammatory and anti-oxidant qualities. This review will deal with the pharmacological properties of curcumin as well as an update of currently available studies in terms of curcumin’s uses and function against organophosphate pesticides-induced toxicity on different human organs.
AB - Organophosphate compounds are regarded as a class of pesticides that are used in farming. Their extensive use, especially in developing countries, is a serious public health problem. Numerous studies have shown the effects of these toxins on vari-ous parts of the human and other vertebrates’ bodies, including the cardiovascular, hepa-tobiliary, renal, and reproductive systems. Curcumin is a polyphenol compound obtained from the rhizome of the Curcuma longa. Curcumin has been known as a dietary spice, food additive, and traditional medicine since many years ago. In recent decades, the medicinal characteristics, clinical aspects, and biological activity of curcumin have been extensively examined. The most examined positive characteristics of curcumin are its an-ti-inflammatory and anti-oxidant qualities. This review will deal with the pharmacological properties of curcumin as well as an update of currently available studies in terms of curcumin’s uses and function against organophosphate pesticides-induced toxicity on different human organs.
KW - Curcumin
KW - organophosphate
KW - pesticides
KW - pesticides
KW - toxicity
KW - toxins
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U2 - 10.2174/0929867329666220817125800
DO - 10.2174/0929867329666220817125800
M3 - Review article
C2 - 35980068
AN - SCOPUS:85151526744
SN - 0929-8673
VL - 30
SP - 2312
EP - 2339
JO - Current medicinal chemistry
JF - Current medicinal chemistry
IS - 20
ER -