Cu Zn superoxide dismutase-like immunoreactivity in Lewy body-like inclusions of sporadic amyotrophic lateral sclerosis

Noriyuki Shibata; Asao Hirano; Makio Kobayashi; Shoichi Sasaki; Kato Takeo; Sadayuki Matsumoto; Zenji Shiozawa; Takashi Komori; Akito Ikemoto; Takahiko Umahara; Kohtaro Asayama

doi:10.1016/0304-3940(94)90956-3

Cu Zn superoxide dismutase-like immunoreactivity in Lewy body-like inclusions of sporadic amyotrophic lateral sclerosis

Noriyuki Shibata, Asao Hirano, Makio Kobayashi, Shoichi Sasaki, Kato Takeo, Sadayuki Matsumoto, Zenji Shiozawa, Takashi Komori, Akito Ikemoto, Takahiko Umahara, Kohtaro Asayama

Research output: Contribution to journal › Article › peer-review

129 Scopus citations

Abstract

Cu Zn superoxide dismutase (SOD)-like immunoreactivity (LI) was found within Lewy body-like inclusions (LBIs) in the spinal cords of patients with sporadic amyotrophic lateral sclerosis (ALS) by using an antibody to human Cu ZnSOD. LBIs were detected in the anterior horn cells in 10 of 20 patients with sporadic ALS. In each of these patients, 7 to 60% of LBIs showed Cu ZnSOD-LI. No Cu ZnSOD-LI was detected in intact neurons and glia in the 20 ALS patients, as well as in these cells in 10 normal control individuals. The skein-like inclusions and Bunina bodies, which were found in all of the 20 ALS cases, showed no Cu ZnSOD-LI. Thus, Cu ZnSOD appears to play roles in the production and/or degradation process of LBIs.

Original language	English (US)
Pages (from-to)	149-152
Number of pages	4
Journal	Neuroscience Letters
Volume	179
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(94)90956-3
State	Published - Sep 26 1994
Externally published	Yes

Keywords

Amyotrophic lateral sclerosis
Bunina body
Immunohistochemistry
Lewy body-like inclusion
Skein-like inclusion
Superoxide dismutase

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(94)90956-3

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@article{e2929a54817f41bdb9556c8883f9ba7f,

title = "Cu Zn superoxide dismutase-like immunoreactivity in Lewy body-like inclusions of sporadic amyotrophic lateral sclerosis",

abstract = "Cu Zn superoxide dismutase (SOD)-like immunoreactivity (LI) was found within Lewy body-like inclusions (LBIs) in the spinal cords of patients with sporadic amyotrophic lateral sclerosis (ALS) by using an antibody to human Cu ZnSOD. LBIs were detected in the anterior horn cells in 10 of 20 patients with sporadic ALS. In each of these patients, 7 to 60% of LBIs showed Cu ZnSOD-LI. No Cu ZnSOD-LI was detected in intact neurons and glia in the 20 ALS patients, as well as in these cells in 10 normal control individuals. The skein-like inclusions and Bunina bodies, which were found in all of the 20 ALS cases, showed no Cu ZnSOD-LI. Thus, Cu ZnSOD appears to play roles in the production and/or degradation process of LBIs.",

keywords = "Amyotrophic lateral sclerosis, Bunina body, Immunohistochemistry, Lewy body-like inclusion, Skein-like inclusion, Superoxide dismutase",

author = "Noriyuki Shibata and Asao Hirano and Makio Kobayashi and Shoichi Sasaki and Kato Takeo and Sadayuki Matsumoto and Zenji Shiozawa and Takashi Komori and Akito Ikemoto and Takahiko Umahara and Kohtaro Asayama",

year = "1994",

month = sep,

day = "26",

doi = "10.1016/0304-3940(94)90956-3",

language = "English (US)",

volume = "179",

pages = "149--152",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "1-2",

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TY - JOUR

T1 - Cu Zn superoxide dismutase-like immunoreactivity in Lewy body-like inclusions of sporadic amyotrophic lateral sclerosis

AU - Shibata, Noriyuki

AU - Hirano, Asao

AU - Kobayashi, Makio

AU - Sasaki, Shoichi

AU - Takeo, Kato

AU - Matsumoto, Sadayuki

AU - Shiozawa, Zenji

AU - Komori, Takashi

AU - Ikemoto, Akito

AU - Umahara, Takahiko

AU - Asayama, Kohtaro

PY - 1994/9/26

Y1 - 1994/9/26

N2 - Cu Zn superoxide dismutase (SOD)-like immunoreactivity (LI) was found within Lewy body-like inclusions (LBIs) in the spinal cords of patients with sporadic amyotrophic lateral sclerosis (ALS) by using an antibody to human Cu ZnSOD. LBIs were detected in the anterior horn cells in 10 of 20 patients with sporadic ALS. In each of these patients, 7 to 60% of LBIs showed Cu ZnSOD-LI. No Cu ZnSOD-LI was detected in intact neurons and glia in the 20 ALS patients, as well as in these cells in 10 normal control individuals. The skein-like inclusions and Bunina bodies, which were found in all of the 20 ALS cases, showed no Cu ZnSOD-LI. Thus, Cu ZnSOD appears to play roles in the production and/or degradation process of LBIs.

AB - Cu Zn superoxide dismutase (SOD)-like immunoreactivity (LI) was found within Lewy body-like inclusions (LBIs) in the spinal cords of patients with sporadic amyotrophic lateral sclerosis (ALS) by using an antibody to human Cu ZnSOD. LBIs were detected in the anterior horn cells in 10 of 20 patients with sporadic ALS. In each of these patients, 7 to 60% of LBIs showed Cu ZnSOD-LI. No Cu ZnSOD-LI was detected in intact neurons and glia in the 20 ALS patients, as well as in these cells in 10 normal control individuals. The skein-like inclusions and Bunina bodies, which were found in all of the 20 ALS cases, showed no Cu ZnSOD-LI. Thus, Cu ZnSOD appears to play roles in the production and/or degradation process of LBIs.

KW - Amyotrophic lateral sclerosis

KW - Bunina body

KW - Immunohistochemistry

KW - Lewy body-like inclusion

KW - Skein-like inclusion

KW - Superoxide dismutase

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U2 - 10.1016/0304-3940(94)90956-3

DO - 10.1016/0304-3940(94)90956-3

M3 - Article

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AN - SCOPUS:0027966078

SN - 0304-3940

VL - 179

SP - 149

EP - 152

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1-2

ER -

Cu Zn superoxide dismutase-like immunoreactivity in Lewy body-like inclusions of sporadic amyotrophic lateral sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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