Cryptococcosis in children with AIDS

Jacobo Abadi, Sharon Nachman, Amy B. Kressel, Liise Anne Pirofski

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


We compiled the clinical and immunologic features of Cryptococcus neoformans infections in human immunodeficiency virus (HIV)-infected children from 1985 to 1996 in a retrospective case series. Thirty cases of cryptococcosis were identified. These children had a median age of 9.8 years, a median CD4+ cell count of 54/μL at the time of diagnosis, and either a culture positive for C. neoformans or cryptococcal antigen in serum or cerebrospinal fluid. Sixty-three percent of the cases occurred in children vertically infected with HIV and in children between 6 and 12 years of age. The clinical and laboratory characteristics of this pediatric cohort were similar to those of adults with AIDS and cryptococcosis. On the basis of a subset of the cases, a 10-year point prevalence of cryptococcosis among children with AIDS of ~1% was estimated.

Original languageEnglish (US)
Pages (from-to)309-313
Number of pages5
JournalClinical Infectious Diseases
Issue number2
StatePublished - 1999

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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