Abstract
One hundred forty‐four serum samples from 52 patients with chronic hepatitis D virus infection were analyzed for hepatitis D virus RNA by dot‐blot hybridization using hepatitis D virus cDNA probe labeled with 32p. The results were correlated with the presence of serum IgM anti‐hepatitis D virus and hepatitis D antigen in liver biopsy specimens when available. Although there was a trend of positive correlation between serum hepatitis D virus RNA and IgM anti‐hepatitis D virus, no statistical significance could be found. In the serum samples with hepatitis D virus RNA, 32% were found to be negative for IgM anti‐hepatitis D virus. Therefore, in chronic hepatitis D virus, absence of IgM anti‐hepatitis D virus does not rule out active viral infection, as suggested by previous studies. There was a strong correlation between serum hepatitis D virus RNA and hepatic hepatitis D virus antigen. These data indicate that detection of hepatitis D virus RNA in serum samples is a reliable noninvasive marker of active viral infection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 34-35 |
| Number of pages | 2 |
| Journal | Hepatology |
| Volume | 10 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 1989 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
ASJC Scopus subject areas
- Hepatology
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