Corneal Complications Related to Dupilumab Use

Jenna Tauber, David C. Ritterband, Joann J. Kang

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives:The aim of this report is to describe atypical corneal complications associated with dupilumab use.Methods:This is a series of four cases of adult patients with infiltrative or ulcerative keratitis secondary to dupilumab use.Results:All four patients in this series were prescribed dupilumab for the treatment of atopic dermatitis and developed infiltrative or ulcerative corneal lesions. In all cases, corneal disease was successfully managed with immediate discontinuation of dupilumab and topical steroid treatment. In two cases, the patient also received antibiotic eye drops for infection precautions.Conclusions:Although dupilumab is most commonly associated with conjunctivitis, physicians should be aware of potential severe corneal complications for early identification and intervention.

Original languageEnglish (US)
Pages (from-to)270-273
Number of pages4
JournalEye and Contact Lens
Volume50
Issue number6
DOIs
StatePublished - Jun 1 2024
Externally publishedYes

Keywords

  • Dupilumab
  • Infiltrative keratitis
  • Ulcerative keratitis

ASJC Scopus subject areas

  • Ophthalmology

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