Controlling the direction of division

Peter Satir

doi:10.1186/scrt21

Controlling the direction of division

Peter Satir

Anatomy & Structural Biology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Quyn and colleagues report that gut stem cells have a biased spindle orientation and asymmetric retention of label-retaining DNA. These features are lost in mouse and human tissues when the microtubule binding protein Apc is mutated. In the developing kidney, Apc acts downstream from primary cilium signaling to influence spindle orientation when noncanonical Wnt signaling predominates. Do gut stem cells also have primary cilia?.

Original language	English (US)
Article number	21
Journal	Stem Cell Research and Therapy
Volume	1
Issue number	3
DOIs	https://doi.org/10.1186/scrt21
State	Published - 2010

ASJC Scopus subject areas

Medicine (miscellaneous)
Molecular Medicine
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Cell Biology

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10.1186/scrt21

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abstract = "Quyn and colleagues report that gut stem cells have a biased spindle orientation and asymmetric retention of label-retaining DNA. These features are lost in mouse and human tissues when the microtubule binding protein Apc is mutated. In the developing kidney, Apc acts downstream from primary cilium signaling to influence spindle orientation when noncanonical Wnt signaling predominates. Do gut stem cells also have primary cilia?.",

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AB - Quyn and colleagues report that gut stem cells have a biased spindle orientation and asymmetric retention of label-retaining DNA. These features are lost in mouse and human tissues when the microtubule binding protein Apc is mutated. In the developing kidney, Apc acts downstream from primary cilium signaling to influence spindle orientation when noncanonical Wnt signaling predominates. Do gut stem cells also have primary cilia?.

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Controlling the direction of division

Abstract

ASJC Scopus subject areas

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