TY - JOUR
T1 - Contributions of adipocyte lipid metabolism to body fat content and implications for the treatment of obesity
AU - Marcelin, Genevieve
AU - Chua, Streamson
PY - 2010/10
Y1 - 2010/10
N2 - Obesity is a chronic disease that increases susceptibility to various diseases, particularly cardiovascular dysfunction, type 2 diabetes, and some types of cancer. In this review, we highlighted recent evidence in mouse models that support a potential benefit of increasing adipose lipid utilization through stimulating lipolysis in adipose tissue and fatty acid oxidation. Brown adipocyte development within white adipose tissue of humans suggests that mouse models may be applicable to human obesity. Consequently, new therapies should target adipose tissue to specifically reduce fat mass through controlled triglyceride utilization.
AB - Obesity is a chronic disease that increases susceptibility to various diseases, particularly cardiovascular dysfunction, type 2 diabetes, and some types of cancer. In this review, we highlighted recent evidence in mouse models that support a potential benefit of increasing adipose lipid utilization through stimulating lipolysis in adipose tissue and fatty acid oxidation. Brown adipocyte development within white adipose tissue of humans suggests that mouse models may be applicable to human obesity. Consequently, new therapies should target adipose tissue to specifically reduce fat mass through controlled triglyceride utilization.
UR - http://www.scopus.com/inward/record.url?scp=77956647929&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956647929&partnerID=8YFLogxK
U2 - 10.1016/j.coph.2010.05.008
DO - 10.1016/j.coph.2010.05.008
M3 - Review article
C2 - 20860920
AN - SCOPUS:77956647929
SN - 1471-4892
VL - 10
SP - 588
EP - 593
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
IS - 5
ER -
