Comparison of methods of evaluating nephrotoxicity of cis-platinum

Brian R. Jones; Ravi B. Bhalla; Jiri Mladek; Ronald N. Kaleya; Richard J. Gralla; Nancy W. Alcock; Morton K. Schwartz; Charles W. Young; Marcus M. Reidenberg

doi:10.1038/clpt.1980.79

Comparison of methods of evaluating nephrotoxicity of cis-platinum

Brian R. Jones, Ravi B. Bhalla, Jiri Mladek, Ronald N. Kaleya, Richard J. Gralla, Nancy W. Alcock, Morton K. Schwartz, Charles W. Young, Marcus M. Reidenberg

Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

The urinary, excretion of leucine aminopeptidase (LAP), N-acetyl-β-glucosaminidase (NAG), and β₂-microglobulin was measured in 12 cancer patients receiving cis-platinum to evaluate the sensitivity, of these indices for renal tubular damage. NAG and LAP excretion rose markedly in all patients, and β₂-microglobulin rose in 11. Seven of the 9 patients who had received cis-platinum 6 wk before the study had prestudy dose elevations of one or more of these indices. We conclude that these urinary proteins are sensitive indicators of proximal renal tubular injury and may provide greater sensitivity for comparison of the nephrotoxic potential of future platinum analogs or for assessing the efficacy, of regimens designed to protect the kidney from platinum nephrotoxicity than other measurements. The persistence of high excretion values for these indices 6 wk after a dose demonstrates the persistent renal injury, by cis-platinum.

Original language	English (US)
Pages (from-to)	557-562
Number of pages	6
Journal	Clinical Pharmacology and Therapeutics
Volume	27
Issue number	4
DOIs	https://doi.org/10.1038/clpt.1980.79
State	Published - Apr 1980

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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10.1038/clpt.1980.79

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@article{12730092a0ed43b986c1ec671e724696,

title = "Comparison of methods of evaluating nephrotoxicity of cis-platinum",

abstract = "The urinary, excretion of leucine aminopeptidase (LAP), N-acetyl-β-glucosaminidase (NAG), and β2-microglobulin was measured in 12 cancer patients receiving cis-platinum to evaluate the sensitivity, of these indices for renal tubular damage. NAG and LAP excretion rose markedly in all patients, and β2-microglobulin rose in 11. Seven of the 9 patients who had received cis-platinum 6 wk before the study had prestudy dose elevations of one or more of these indices. We conclude that these urinary proteins are sensitive indicators of proximal renal tubular injury and may provide greater sensitivity for comparison of the nephrotoxic potential of future platinum analogs or for assessing the efficacy, of regimens designed to protect the kidney from platinum nephrotoxicity than other measurements. The persistence of high excretion values for these indices 6 wk after a dose demonstrates the persistent renal injury, by cis-platinum.",

author = "Jones, {Brian R.} and Bhalla, {Ravi B.} and Jiri Mladek and Kaleya, {Ronald N.} and Gralla, {Richard J.} and Alcock, {Nancy W.} and Schwartz, {Morton K.} and Young, {Charles W.} and Reidenberg, {Marcus M.}",

year = "1980",

month = apr,

doi = "10.1038/clpt.1980.79",

language = "English (US)",

volume = "27",

pages = "557--562",

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T1 - Comparison of methods of evaluating nephrotoxicity of cis-platinum

AU - Jones, Brian R.

AU - Bhalla, Ravi B.

AU - Mladek, Jiri

AU - Kaleya, Ronald N.

AU - Gralla, Richard J.

AU - Alcock, Nancy W.

AU - Schwartz, Morton K.

AU - Young, Charles W.

AU - Reidenberg, Marcus M.

PY - 1980/4

Y1 - 1980/4

N2 - The urinary, excretion of leucine aminopeptidase (LAP), N-acetyl-β-glucosaminidase (NAG), and β2-microglobulin was measured in 12 cancer patients receiving cis-platinum to evaluate the sensitivity, of these indices for renal tubular damage. NAG and LAP excretion rose markedly in all patients, and β2-microglobulin rose in 11. Seven of the 9 patients who had received cis-platinum 6 wk before the study had prestudy dose elevations of one or more of these indices. We conclude that these urinary proteins are sensitive indicators of proximal renal tubular injury and may provide greater sensitivity for comparison of the nephrotoxic potential of future platinum analogs or for assessing the efficacy, of regimens designed to protect the kidney from platinum nephrotoxicity than other measurements. The persistence of high excretion values for these indices 6 wk after a dose demonstrates the persistent renal injury, by cis-platinum.

AB - The urinary, excretion of leucine aminopeptidase (LAP), N-acetyl-β-glucosaminidase (NAG), and β2-microglobulin was measured in 12 cancer patients receiving cis-platinum to evaluate the sensitivity, of these indices for renal tubular damage. NAG and LAP excretion rose markedly in all patients, and β2-microglobulin rose in 11. Seven of the 9 patients who had received cis-platinum 6 wk before the study had prestudy dose elevations of one or more of these indices. We conclude that these urinary proteins are sensitive indicators of proximal renal tubular injury and may provide greater sensitivity for comparison of the nephrotoxic potential of future platinum analogs or for assessing the efficacy, of regimens designed to protect the kidney from platinum nephrotoxicity than other measurements. The persistence of high excretion values for these indices 6 wk after a dose demonstrates the persistent renal injury, by cis-platinum.

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JO - Clinical Pharmacology and Therapeutics

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ER -

Comparison of methods of evaluating nephrotoxicity of cis-platinum

Abstract

ASJC Scopus subject areas

UN SDGs

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