Comparison of Bethesda cytopathology classification to surgical pathology across racial-ethnic groups

Amishav Bresler; Vikas Mehta; Bradley A. Schiff; Richard V. Smith; Samer Khader; Gloria Ramos-Rivera; Juan Lin; Steven K. Libutti; Amanda M. Laird; Thomas J. Ow

doi:10.1002/hed.25707

Comparison of Bethesda cytopathology classification to surgical pathology across racial-ethnic groups

Amishav Bresler, Vikas Mehta, Bradley A. Schiff, Richard V. Smith, Samer Khader, Gloria Ramos-Rivera, Juan Lin, Steven K. Libutti, Amanda M. Laird, Thomas J. Ow

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background: The Bethesda System standardized the reporting of thyroid cytopathology and created categories to provide an estimation of a nodule's risk of malignancy. There are limited data describing their utility in different racial-ethnic groups. Methods: A retrospective chart review of thyroid fine-needle aspirations (FNA) was performed within our health-care systems. Sensitivity, specificity, positive predictive value (PPV), and negative predictive values (NPVs) were calculated for the total cohort, and racial-ethnic groups. Results: The sensitivity, specificity, PPV, and NPV of the entire cohort was 93%, 77%, 57%, and 97%. Among patients who underwent surgery, African Americans contained a high number of Bethesda II FNAs (63%) compared to Hispanics (48%) and whites (45%). The sensitivity, specificity, and NPV were comparable among groups, the PPV was lowest for African Americans (43%), followed by Hispanics (60%) and whites (69%). Conclusions: The Bethesda system's predictive value may differ among racial-ethnic groups.

Original language	English (US)
Pages (from-to)	2340-2345
Number of pages	6
Journal	Head and Neck
Volume	41
Issue number	7
DOIs	https://doi.org/10.1002/hed.25707
State	Published - Jul 2019

Keywords

Bethesda system
fine-needle aspiration biopsy
prevalence
test characteristics
thyroid

ASJC Scopus subject areas

Otorhinolaryngology

Access to Document

10.1002/hed.25707

Cite this

@article{101d257e5b6349c1a4187ae82434f6ce,

title = "Comparison of Bethesda cytopathology classification to surgical pathology across racial-ethnic groups",

abstract = "Background: The Bethesda System standardized the reporting of thyroid cytopathology and created categories to provide an estimation of a nodule's risk of malignancy. There are limited data describing their utility in different racial-ethnic groups. Methods: A retrospective chart review of thyroid fine-needle aspirations (FNA) was performed within our health-care systems. Sensitivity, specificity, positive predictive value (PPV), and negative predictive values (NPVs) were calculated for the total cohort, and racial-ethnic groups. Results: The sensitivity, specificity, PPV, and NPV of the entire cohort was 93%, 77%, 57%, and 97%. Among patients who underwent surgery, African Americans contained a high number of Bethesda II FNAs (63%) compared to Hispanics (48%) and whites (45%). The sensitivity, specificity, and NPV were comparable among groups, the PPV was lowest for African Americans (43%), followed by Hispanics (60%) and whites (69%). Conclusions: The Bethesda system's predictive value may differ among racial-ethnic groups.",

keywords = "Bethesda system, fine-needle aspiration biopsy, prevalence, test characteristics, thyroid",

author = "Amishav Bresler and Vikas Mehta and Schiff, {Bradley A.} and Smith, {Richard V.} and Samer Khader and Gloria Ramos-Rivera and Juan Lin and Libutti, {Steven K.} and Laird, {Amanda M.} and Ow, {Thomas J.}",

note = "Publisher Copyright: {\textcopyright} 2019 Wiley Periodicals, Inc.",

year = "2019",

month = jul,

doi = "10.1002/hed.25707",

language = "English (US)",

volume = "41",

pages = "2340--2345",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "Wiley-Liss Inc.",

number = "7",

}

TY - JOUR

T1 - Comparison of Bethesda cytopathology classification to surgical pathology across racial-ethnic groups

AU - Bresler, Amishav

AU - Mehta, Vikas

AU - Schiff, Bradley A.

AU - Smith, Richard V.

AU - Khader, Samer

AU - Ramos-Rivera, Gloria

AU - Lin, Juan

AU - Libutti, Steven K.

AU - Laird, Amanda M.

AU - Ow, Thomas J.

PY - 2019/7

Y1 - 2019/7

N2 - Background: The Bethesda System standardized the reporting of thyroid cytopathology and created categories to provide an estimation of a nodule's risk of malignancy. There are limited data describing their utility in different racial-ethnic groups. Methods: A retrospective chart review of thyroid fine-needle aspirations (FNA) was performed within our health-care systems. Sensitivity, specificity, positive predictive value (PPV), and negative predictive values (NPVs) were calculated for the total cohort, and racial-ethnic groups. Results: The sensitivity, specificity, PPV, and NPV of the entire cohort was 93%, 77%, 57%, and 97%. Among patients who underwent surgery, African Americans contained a high number of Bethesda II FNAs (63%) compared to Hispanics (48%) and whites (45%). The sensitivity, specificity, and NPV were comparable among groups, the PPV was lowest for African Americans (43%), followed by Hispanics (60%) and whites (69%). Conclusions: The Bethesda system's predictive value may differ among racial-ethnic groups.

AB - Background: The Bethesda System standardized the reporting of thyroid cytopathology and created categories to provide an estimation of a nodule's risk of malignancy. There are limited data describing their utility in different racial-ethnic groups. Methods: A retrospective chart review of thyroid fine-needle aspirations (FNA) was performed within our health-care systems. Sensitivity, specificity, positive predictive value (PPV), and negative predictive values (NPVs) were calculated for the total cohort, and racial-ethnic groups. Results: The sensitivity, specificity, PPV, and NPV of the entire cohort was 93%, 77%, 57%, and 97%. Among patients who underwent surgery, African Americans contained a high number of Bethesda II FNAs (63%) compared to Hispanics (48%) and whites (45%). The sensitivity, specificity, and NPV were comparable among groups, the PPV was lowest for African Americans (43%), followed by Hispanics (60%) and whites (69%). Conclusions: The Bethesda system's predictive value may differ among racial-ethnic groups.

KW - Bethesda system

KW - fine-needle aspiration biopsy

KW - prevalence

KW - test characteristics

KW - thyroid

UR - http://www.scopus.com/inward/record.url?scp=85067568968&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067568968&partnerID=8YFLogxK

U2 - 10.1002/hed.25707

DO - 10.1002/hed.25707

M3 - Article

C2 - 30793405

AN - SCOPUS:85067568968

SN - 1043-3074

VL - 41

SP - 2340

EP - 2345

JO - Head and Neck

JF - Head and Neck

IS - 7

ER -

Comparison of Bethesda cytopathology classification to surgical pathology across racial-ethnic groups

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this