Mammals have evolved a remarkable diversity of ageing rates. Within the single order of Rodentia, maximum lifespans range from 4 years in mice to 32 years in naked mole rats. Cancer rates also differ substantially between cancer-prone mice and almost cancer-proof naked mole rats and blind mole rats. Recent progress in rodent comparative biology, together with the emergence of whole-genome sequence information, has opened opportunities for the discovery of genetic factors that control longevity and cancer susceptibility.
|Original language||English (US)|
|Number of pages||10|
|Journal||Nature Reviews Genetics|
|State||Published - Aug 2014|
ASJC Scopus subject areas
- Molecular Biology