Comparative genetics of longevity and cancer: Insights from long-lived rodents

Vera Gorbunova; Andrei Seluanov; Zhengdong Zhang; Vadim N. Gladyshev; Jan Vijg

doi:10.1038/nrg3728

Comparative genetics of longevity and cancer: Insights from long-lived rodents

Vera Gorbunova, Andrei Seluanov, Zhengdong Zhang, Vadim N. Gladyshev, Jan Vijg

Genetics

Research output: Contribution to journal › Review article › peer-review

162 Scopus citations

Abstract

Mammals have evolved a remarkable diversity of ageing rates. Within the single order of Rodentia, maximum lifespans range from 4 years in mice to 32 years in naked mole rats. Cancer rates also differ substantially between cancer-prone mice and almost cancer-proof naked mole rats and blind mole rats. Recent progress in rodent comparative biology, together with the emergence of whole-genome sequence information, has opened opportunities for the discovery of genetic factors that control longevity and cancer susceptibility.

Original language	English (US)
Pages (from-to)	531-540
Number of pages	10
Journal	Nature Reviews Genetics
Volume	15
Issue number	8
DOIs	https://doi.org/10.1038/nrg3728
State	Published - Aug 2014

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nrg3728

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title = "Comparative genetics of longevity and cancer: Insights from long-lived rodents",

abstract = "Mammals have evolved a remarkable diversity of ageing rates. Within the single order of Rodentia, maximum lifespans range from 4 years in mice to 32 years in naked mole rats. Cancer rates also differ substantially between cancer-prone mice and almost cancer-proof naked mole rats and blind mole rats. Recent progress in rodent comparative biology, together with the emergence of whole-genome sequence information, has opened opportunities for the discovery of genetic factors that control longevity and cancer susceptibility.",

author = "Vera Gorbunova and Andrei Seluanov and Zhengdong Zhang and Gladyshev, {Vadim N.} and Jan Vijg",

note = "Funding Information: The authors thank D. Promislow and M. van Meter for comments on the manuscript, and I. Seim for help with the figures. The work in the authors{\textquoteright} laboratories is supported by the US National Institutes of Health (all authors); the Life Extension Foundation (V.G. and A.S.); and the Glenn Foundation for Medical Research (J.V.). The authors thank past and present members of their laboratories for their insights.",

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AU - Gorbunova, Vera

AU - Seluanov, Andrei

AU - Zhang, Zhengdong

AU - Gladyshev, Vadim N.

AU - Vijg, Jan

N1 - Funding Information: The authors thank D. Promislow and M. van Meter for comments on the manuscript, and I. Seim for help with the figures. The work in the authors’ laboratories is supported by the US National Institutes of Health (all authors); the Life Extension Foundation (V.G. and A.S.); and the Glenn Foundation for Medical Research (J.V.). The authors thank past and present members of their laboratories for their insights.

PY - 2014/8

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N2 - Mammals have evolved a remarkable diversity of ageing rates. Within the single order of Rodentia, maximum lifespans range from 4 years in mice to 32 years in naked mole rats. Cancer rates also differ substantially between cancer-prone mice and almost cancer-proof naked mole rats and blind mole rats. Recent progress in rodent comparative biology, together with the emergence of whole-genome sequence information, has opened opportunities for the discovery of genetic factors that control longevity and cancer susceptibility.

AB - Mammals have evolved a remarkable diversity of ageing rates. Within the single order of Rodentia, maximum lifespans range from 4 years in mice to 32 years in naked mole rats. Cancer rates also differ substantially between cancer-prone mice and almost cancer-proof naked mole rats and blind mole rats. Recent progress in rodent comparative biology, together with the emergence of whole-genome sequence information, has opened opportunities for the discovery of genetic factors that control longevity and cancer susceptibility.

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Comparative genetics of longevity and cancer: Insights from long-lived rodents

Abstract

ASJC Scopus subject areas

UN SDGs

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