Common diseases alter the physiological age-related blood microRNA profile

Tobias Fehlmann; Benoit Lehallier; Nicholas Schaum; Oliver Hahn; Mustafa Kahraman; Yongping Li; Nadja Grammes; Lars Geffers; Christina Backes; Rudi Balling; Fabian Kern; Rejko Krüger; Frank Lammert; Nicole Ludwig; Benjamin Meder; Bastian Fromm; Walter Maetzler; Daniela Berg; Kathrin Brockmann; Christian Deuschle; Anna Katharina von Thaler; Gerhard W. Eschweiler; Sofiya Milman; Nir Barziliai; Matthias Reichert; Tony Wyss-Coray; Eckart Meese; Andreas Keller

doi:10.1038/s41467-020-19665-1

Common diseases alter the physiological age-related blood microRNA profile

Tobias Fehlmann, Benoit Lehallier, Nicholas Schaum, Oliver Hahn, Mustafa Kahraman, Yongping Li, Nadja Grammes, Lars Geffers, Christina Backes, Rudi Balling, Fabian Kern, Rejko Krüger, Frank Lammert, Nicole Ludwig, Benjamin Meder, Bastian Fromm, Walter Maetzler, Daniela Berg, Kathrin Brockmann, Christian DeuschleAnna Katharina von Thaler, Gerhard W. Eschweiler, Sofiya Milman, Nir Barziliai, Matthias Reichert, Tony Wyss-Coray, Eckart Meese, Andreas Keller

Medicine

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Aging is a key risk factor for chronic diseases of the elderly. MicroRNAs regulate post-transcriptional gene silencing through base-pair binding on their target mRNAs. We identified nonlinear changes in age-related microRNAs by analyzing whole blood from 1334 healthy individuals. We observed a larger influence of the age as compared to the sex and provide evidence for a shift to the 5’ mature form of miRNAs in healthy aging. The addition of 3059 diseased patients uncovered pan-disease and disease-specific alterations in aging profiles. Disease biomarker sets for all diseases were different between young and old patients. Computational deconvolution of whole-blood miRNAs into blood cell types suggests that cell intrinsic gene expression changes may impart greater significance than cell abundance changes to the whole blood miRNA profile. Altogether, these data provide a foundation for understanding the relationship between healthy aging and disease, and for the development of age-specific disease biomarkers.

Original language	English (US)
Article number	5958
Journal	Nature communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-19665-1
State	Published - Dec 2020

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

Access to Document

10.1038/s41467-020-19665-1

Cite this

Fehlmann, T., Lehallier, B., Schaum, N., Hahn, O., Kahraman, M., Li, Y., Grammes, N., Geffers, L., Backes, C., Balling, R., Kern, F., Krüger, R., Lammert, F., Ludwig, N., Meder, B., Fromm, B., Maetzler, W., Berg, D., Brockmann, K., ... Keller, A. (2020). Common diseases alter the physiological age-related blood microRNA profile. Nature communications, 11(1), Article 5958. https://doi.org/10.1038/s41467-020-19665-1

Fehlmann, T, Lehallier, B, Schaum, N, Hahn, O, Kahraman, M, Li, Y, Grammes, N, Geffers, L, Backes, C, Balling, R, Kern, F, Krüger, R, Lammert, F, Ludwig, N, Meder, B, Fromm, B, Maetzler, W, Berg, D, Brockmann, K, Deuschle, C, von Thaler, AK, Eschweiler, GW, Milman, S, Barziliai, N, Reichert, M, Wyss-Coray, T, Meese, E & Keller, A 2020, 'Common diseases alter the physiological age-related blood microRNA profile', Nature communications, vol. 11, no. 1, 5958. https://doi.org/10.1038/s41467-020-19665-1

@article{a8509eb49e7a4d28a8d6b280057a6174,

title = "Common diseases alter the physiological age-related blood microRNA profile",

abstract = "Aging is a key risk factor for chronic diseases of the elderly. MicroRNAs regulate post-transcriptional gene silencing through base-pair binding on their target mRNAs. We identified nonlinear changes in age-related microRNAs by analyzing whole blood from 1334 healthy individuals. We observed a larger influence of the age as compared to the sex and provide evidence for a shift to the 5{\textquoteright} mature form of miRNAs in healthy aging. The addition of 3059 diseased patients uncovered pan-disease and disease-specific alterations in aging profiles. Disease biomarker sets for all diseases were different between young and old patients. Computational deconvolution of whole-blood miRNAs into blood cell types suggests that cell intrinsic gene expression changes may impart greater significance than cell abundance changes to the whole blood miRNA profile. Altogether, these data provide a foundation for understanding the relationship between healthy aging and disease, and for the development of age-specific disease biomarkers.",

author = "Tobias Fehlmann and Benoit Lehallier and Nicholas Schaum and Oliver Hahn and Mustafa Kahraman and Yongping Li and Nadja Grammes and Lars Geffers and Christina Backes and Rudi Balling and Fabian Kern and Rejko Kr{\"u}ger and Frank Lammert and Nicole Ludwig and Benjamin Meder and Bastian Fromm and Walter Maetzler and Daniela Berg and Kathrin Brockmann and Christian Deuschle and {von Thaler}, {Anna Katharina} and Eschweiler, {Gerhard W.} and Sofiya Milman and Nir Barziliai and Matthias Reichert and Tony Wyss-Coray and Eckart Meese and Andreas Keller",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s).",

year = "2020",

month = dec,

doi = "10.1038/s41467-020-19665-1",

language = "English (US)",

volume = "11",

journal = "Nature communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - Common diseases alter the physiological age-related blood microRNA profile

AU - Fehlmann, Tobias

AU - Lehallier, Benoit

AU - Schaum, Nicholas

AU - Hahn, Oliver

AU - Kahraman, Mustafa

AU - Li, Yongping

AU - Grammes, Nadja

AU - Geffers, Lars

AU - Backes, Christina

AU - Balling, Rudi

AU - Kern, Fabian

AU - Krüger, Rejko

AU - Lammert, Frank

AU - Ludwig, Nicole

AU - Meder, Benjamin

AU - Fromm, Bastian

AU - Maetzler, Walter

AU - Berg, Daniela

AU - Brockmann, Kathrin

AU - Deuschle, Christian

AU - von Thaler, Anna Katharina

AU - Eschweiler, Gerhard W.

AU - Milman, Sofiya

AU - Barziliai, Nir

AU - Reichert, Matthias

AU - Wyss-Coray, Tony

AU - Meese, Eckart

AU - Keller, Andreas

PY - 2020/12

Y1 - 2020/12

N2 - Aging is a key risk factor for chronic diseases of the elderly. MicroRNAs regulate post-transcriptional gene silencing through base-pair binding on their target mRNAs. We identified nonlinear changes in age-related microRNAs by analyzing whole blood from 1334 healthy individuals. We observed a larger influence of the age as compared to the sex and provide evidence for a shift to the 5’ mature form of miRNAs in healthy aging. The addition of 3059 diseased patients uncovered pan-disease and disease-specific alterations in aging profiles. Disease biomarker sets for all diseases were different between young and old patients. Computational deconvolution of whole-blood miRNAs into blood cell types suggests that cell intrinsic gene expression changes may impart greater significance than cell abundance changes to the whole blood miRNA profile. Altogether, these data provide a foundation for understanding the relationship between healthy aging and disease, and for the development of age-specific disease biomarkers.

AB - Aging is a key risk factor for chronic diseases of the elderly. MicroRNAs regulate post-transcriptional gene silencing through base-pair binding on their target mRNAs. We identified nonlinear changes in age-related microRNAs by analyzing whole blood from 1334 healthy individuals. We observed a larger influence of the age as compared to the sex and provide evidence for a shift to the 5’ mature form of miRNAs in healthy aging. The addition of 3059 diseased patients uncovered pan-disease and disease-specific alterations in aging profiles. Disease biomarker sets for all diseases were different between young and old patients. Computational deconvolution of whole-blood miRNAs into blood cell types suggests that cell intrinsic gene expression changes may impart greater significance than cell abundance changes to the whole blood miRNA profile. Altogether, these data provide a foundation for understanding the relationship between healthy aging and disease, and for the development of age-specific disease biomarkers.

UR - http://www.scopus.com/inward/record.url?scp=85096593154&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85096593154&partnerID=8YFLogxK

U2 - 10.1038/s41467-020-19665-1

DO - 10.1038/s41467-020-19665-1

M3 - Article

C2 - 33235214

AN - SCOPUS:85096593154

SN - 2041-1723

VL - 11

JO - Nature communications

JF - Nature communications

IS - 1

M1 - 5958

ER -

Common diseases alter the physiological age-related blood microRNA profile

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this