Combination of 5-flucytosine and capsule-binding monoclonal antibody in the treatment of murine Cryptococcus neoformans infections and in vitro

Marta Feldmesser; Jean Mukherjee; Arturo Casadevall

doi:10.1093/jac/37.3.617

Combination of 5-flucytosine and capsule-binding monoclonal antibody in the treatment of murine Cryptococcus neoformans infections and in vitro

Marta Feldmesser
, Jean Mukherjee
, Arturo Casadevall

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

The efficacy of combination therapy with 5-flucytosine and an IgG1 monoclonal antibody to Cryptococcus neoformans capsular glucuronoxylomannan was studied in vitro with J774.16 murine macrophage-like cells and in vivo in murine cryptococcal infection. The combination of 5-flucytosine and IgG1 was more effective in reducing the numbers of C. neoformans colony-forming units in vitro and in vivo than either agent alone.

Original language	English (US)
Pages (from-to)	617-622
Number of pages	6
Journal	Journal of Antimicrobial Chemotherapy
Volume	37
Issue number	3
DOIs	https://doi.org/10.1093/jac/37.3.617
State	Published - 1996

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Pharmacology
Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

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10.1093/jac/37.3.617

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title = "Combination of 5-flucytosine and capsule-binding monoclonal antibody in the treatment of murine Cryptococcus neoformans infections and in vitro",

abstract = "The efficacy of combination therapy with 5-flucytosine and an IgG1 monoclonal antibody to Cryptococcus neoformans capsular glucuronoxylomannan was studied in vitro with J774.16 murine macrophage-like cells and in vivo in murine cryptococcal infection. The combination of 5-flucytosine and IgG1 was more effective in reducing the numbers of C. neoformans colony-forming units in vitro and in vivo than either agent alone.",

author = "Marta Feldmesser and Jean Mukherjee and Arturo Casadevall",

note = "Funding Information: The data in this paper were presented at The Second National Conference on Human Retroviruses and Related Infections in Washington, DC in January 1995. A. C. is supported by a James S. McDonnell Scholar Award and NIH grants RO1-A 133774 and RO1-A113342. M. F. is supported by NIH grant AI07183-14 ST32. J. M. is supported by NIH grant 5R32 CA39838. We would like to thank Dr Chee Jen Chang for his assistance with statistical analysis.",

year = "1996",

doi = "10.1093/jac/37.3.617",

language = "English (US)",

volume = "37",

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AU - Feldmesser, Marta

AU - Mukherjee, Jean

AU - Casadevall, Arturo

N1 - Funding Information: The data in this paper were presented at The Second National Conference on Human Retroviruses and Related Infections in Washington, DC in January 1995. A. C. is supported by a James S. McDonnell Scholar Award and NIH grants RO1-A 133774 and RO1-A113342. M. F. is supported by NIH grant AI07183-14 ST32. J. M. is supported by NIH grant 5R32 CA39838. We would like to thank Dr Chee Jen Chang for his assistance with statistical analysis.

PY - 1996

Y1 - 1996

N2 - The efficacy of combination therapy with 5-flucytosine and an IgG1 monoclonal antibody to Cryptococcus neoformans capsular glucuronoxylomannan was studied in vitro with J774.16 murine macrophage-like cells and in vivo in murine cryptococcal infection. The combination of 5-flucytosine and IgG1 was more effective in reducing the numbers of C. neoformans colony-forming units in vitro and in vivo than either agent alone.

AB - The efficacy of combination therapy with 5-flucytosine and an IgG1 monoclonal antibody to Cryptococcus neoformans capsular glucuronoxylomannan was studied in vitro with J774.16 murine macrophage-like cells and in vivo in murine cryptococcal infection. The combination of 5-flucytosine and IgG1 was more effective in reducing the numbers of C. neoformans colony-forming units in vitro and in vivo than either agent alone.

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Combination of 5-flucytosine and capsule-binding monoclonal antibody in the treatment of murine Cryptococcus neoformans infections and in vitro

Abstract

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