Coiled-coils in phage display screening: Insight into exceptional selectivity provided by molecular dynamics

Jérémie Mortier; Elisabeth K. Nyakatura; Oliver Reimann; Susanne Huhmann; Jan O. Daldrop; Carsten Baldauf; Gerhard Wolber; Markus S. Miettinen; Beate Koksch

doi:10.1021/ci500689c

Coiled-coils in phage display screening: Insight into exceptional selectivity provided by molecular dynamics

Jérémie Mortier
, Elisabeth K. Nyakatura
, Oliver Reimann
, Susanne Huhmann
, Jan O. Daldrop
, Carsten Baldauf
, Gerhard Wolber
, Markus S. Miettinen
, Beate Koksch

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Involved in numerous key biological functions, protein helix-helix interactions follow a well-defined intermolecular recognition pattern. The characteristic structure of the ±-helical coiled-coil allows for the specific randomization of clearly defined interaction partners within heteromeric systems. In this work, a rationally designed heterodimeric coiled-coil was used to investigate potential factors influencing the sequence selectivity in interhelical interactions.

Original language	English (US)
Pages (from-to)	495-500
Number of pages	6
Journal	Journal of Chemical Information and Modeling
Volume	55
Issue number	3
DOIs	https://doi.org/10.1021/ci500689c
State	Published - Mar 23 2015
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering
Computer Science Applications
Library and Information Sciences

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10.1021/ci500689c

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abstract = "Involved in numerous key biological functions, protein helix-helix interactions follow a well-defined intermolecular recognition pattern. The characteristic structure of the ±-helical coiled-coil allows for the specific randomization of clearly defined interaction partners within heteromeric systems. In this work, a rationally designed heterodimeric coiled-coil was used to investigate potential factors influencing the sequence selectivity in interhelical interactions.",

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T2 - Insight into exceptional selectivity provided by molecular dynamics

AU - Mortier, Jérémie

AU - Nyakatura, Elisabeth K.

AU - Reimann, Oliver

AU - Huhmann, Susanne

AU - Daldrop, Jan O.

AU - Baldauf, Carsten

AU - Wolber, Gerhard

AU - Miettinen, Markus S.

AU - Koksch, Beate

PY - 2015/3/23

Y1 - 2015/3/23

N2 - Involved in numerous key biological functions, protein helix-helix interactions follow a well-defined intermolecular recognition pattern. The characteristic structure of the ±-helical coiled-coil allows for the specific randomization of clearly defined interaction partners within heteromeric systems. In this work, a rationally designed heterodimeric coiled-coil was used to investigate potential factors influencing the sequence selectivity in interhelical interactions.

AB - Involved in numerous key biological functions, protein helix-helix interactions follow a well-defined intermolecular recognition pattern. The characteristic structure of the ±-helical coiled-coil allows for the specific randomization of clearly defined interaction partners within heteromeric systems. In this work, a rationally designed heterodimeric coiled-coil was used to investigate potential factors influencing the sequence selectivity in interhelical interactions.

UR - https://www.scopus.com/pages/publications/84925397458

UR - https://www.scopus.com/pages/publications/84925397458#tab=citedBy

U2 - 10.1021/ci500689c

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AN - SCOPUS:84925397458

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JF - Journal of Chemical Information and Modeling

IS - 3

ER -

Coiled-coils in phage display screening: Insight into exceptional selectivity provided by molecular dynamics

Abstract

ASJC Scopus subject areas

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