Coiled-coils in phage display screening: Insight into exceptional selectivity provided by molecular dynamics

Jérémie Mortier; Elisabeth K. Nyakatura; Oliver Reimann; Susanne Huhmann; Jan O. Daldrop; Carsten Baldauf; Gerhard Wolber; Markus S. Miettinen; Beate Koksch

doi:10.1021/ci500689c

Coiled-coils in phage display screening: Insight into exceptional selectivity provided by molecular dynamics

Jérémie Mortier, Elisabeth K. Nyakatura, Oliver Reimann, Susanne Huhmann, Jan O. Daldrop, Carsten Baldauf, Gerhard Wolber, Markus S. Miettinen, Beate Koksch

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Involved in numerous key biological functions, protein helix-helix interactions follow a well-defined intermolecular recognition pattern. The characteristic structure of the ±-helical coiled-coil allows for the specific randomization of clearly defined interaction partners within heteromeric systems. In this work, a rationally designed heterodimeric coiled-coil was used to investigate potential factors influencing the sequence selectivity in interhelical interactions.

Original language	English (US)
Pages (from-to)	495-500
Number of pages	6
Journal	Journal of Chemical Information and Modeling
Volume	55
Issue number	3
DOIs	https://doi.org/10.1021/ci500689c
State	Published - Mar 23 2015
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering
Computer Science Applications
Library and Information Sciences

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10.1021/ci500689c

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abstract = "Involved in numerous key biological functions, protein helix-helix interactions follow a well-defined intermolecular recognition pattern. The characteristic structure of the ±-helical coiled-coil allows for the specific randomization of clearly defined interaction partners within heteromeric systems. In this work, a rationally designed heterodimeric coiled-coil was used to investigate potential factors influencing the sequence selectivity in interhelical interactions.",

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AU - Mortier, Jérémie

AU - Nyakatura, Elisabeth K.

AU - Reimann, Oliver

AU - Huhmann, Susanne

AU - Daldrop, Jan O.

AU - Baldauf, Carsten

AU - Wolber, Gerhard

AU - Miettinen, Markus S.

AU - Koksch, Beate

PY - 2015/3/23

Y1 - 2015/3/23

N2 - Involved in numerous key biological functions, protein helix-helix interactions follow a well-defined intermolecular recognition pattern. The characteristic structure of the ±-helical coiled-coil allows for the specific randomization of clearly defined interaction partners within heteromeric systems. In this work, a rationally designed heterodimeric coiled-coil was used to investigate potential factors influencing the sequence selectivity in interhelical interactions.

AB - Involved in numerous key biological functions, protein helix-helix interactions follow a well-defined intermolecular recognition pattern. The characteristic structure of the ±-helical coiled-coil allows for the specific randomization of clearly defined interaction partners within heteromeric systems. In this work, a rationally designed heterodimeric coiled-coil was used to investigate potential factors influencing the sequence selectivity in interhelical interactions.

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Coiled-coils in phage display screening: Insight into exceptional selectivity provided by molecular dynamics

Abstract

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