Cognitive Changes with Reproductive Aging, Perimenopause, and Menopause

Kelly N. Morgan, Carol A. Derby, Carey E. Gleason

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


This article reviews the role of endogenous estrogen in neural and cognitive processing, followed by an examination of longitudinal cognitive data captured in various stages of the menopausal transition. The remaining text reviews the contradictory results from major hormone therapy trials to date, evidence for the “timing hypothesis,” and closes with recommendations for future research and for practicing clinicians.

Original languageEnglish (US)
Pages (from-to)751-763
Number of pages13
JournalObstetrics and Gynecology Clinics of North America
Issue number4
StatePublished - Dec 2018


  • Cognition
  • Early versus late intervention trial with estradiol
  • Estrogens
  • Hormone therapy
  • Kronos early estrogen prevention study
  • Menopause
  • Study of women across the nation
  • Women's Health Initiative

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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