TY - JOUR
T1 - Clostridium difficile‐Associated Diarrhea in Patients with HIV Positivity and AIDS
T2 - A Prospective Controlled Study
AU - Lu, Sain Sain
AU - Schwartz, Jonathan M.
AU - Simon, Douglas M.
AU - Brandt, Lawrence J.
PY - 1994/8
Y1 - 1994/8
N2 - Objective: To compare the clinical manifestations and therapeutic responses of Clostridium difficile infection in HIV‐infected and noninfected individuals. Methods: Patients were identified for this study if they had C. difficile toxin in the stool. The patients were then followed prospectively by the investigators. All patients were treated with a standard regimen, and clinical and laboratory findings were recorded. Persistence and resolution or recurrence of symptoms and complications were recorded. Results: A total of 87 patients were studied, of which 12 were HIV positive, 20 had AIDS, and 55 had no known HIV infection. The AIDS group was younger and had a lower total leukocyte count than the controls. There were no statistically significant differences in temperature, leukocytosis, clinical symptoms, therapeutic response, or recurrence or persistent of symptoms. Conclusions: Despite the immuno‐suppression of HIV infection, C. difficile infection behaves no differently in HIV/AIDS patients than it does in controls.
AB - Objective: To compare the clinical manifestations and therapeutic responses of Clostridium difficile infection in HIV‐infected and noninfected individuals. Methods: Patients were identified for this study if they had C. difficile toxin in the stool. The patients were then followed prospectively by the investigators. All patients were treated with a standard regimen, and clinical and laboratory findings were recorded. Persistence and resolution or recurrence of symptoms and complications were recorded. Results: A total of 87 patients were studied, of which 12 were HIV positive, 20 had AIDS, and 55 had no known HIV infection. The AIDS group was younger and had a lower total leukocyte count than the controls. There were no statistically significant differences in temperature, leukocytosis, clinical symptoms, therapeutic response, or recurrence or persistent of symptoms. Conclusions: Despite the immuno‐suppression of HIV infection, C. difficile infection behaves no differently in HIV/AIDS patients than it does in controls.
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U2 - 10.1111/j.1572-0241.1994.tb10280.x
DO - 10.1111/j.1572-0241.1994.tb10280.x
M3 - Article
C2 - 8053439
AN - SCOPUS:0027936691
SN - 0002-9270
VL - 89
SP - 1226
EP - 1229
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 8
ER -
