Closing the gap: long-term presynaptic plasticity in brain function and disease

Hannah R. Monday, Pablo E. Castillo

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Synaptic plasticity is critical for experience-dependent adjustments of brain function. While most research has focused on the mechanisms that underlie postsynaptic forms of plasticity, comparatively little is known about how neurotransmitter release is altered in a long-term manner. Emerging research suggests that many of the features of canonical ‘postsynaptic’ plasticity, such as associativity, structural changes and bidirectionality, also characterize long-term presynaptic plasticity. Recent studies demonstrate that presynaptic plasticity is a potent regulator of circuit output and function. Moreover, aberrant presynaptic plasticity is a convergent factor of synaptopathies like schizophrenia, addiction, and Autism Spectrum Disorders, and may be a potential target for treatment.

Original languageEnglish (US)
Pages (from-to)106-112
Number of pages7
JournalCurrent Opinion in Neurobiology
StatePublished - Aug 2017

ASJC Scopus subject areas

  • Neuroscience(all)


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