Clonal growth in vitro by mouse Kupffer cells

Dien Ming Chen, Hsiu San Lin, Philip Stahl, E. Richard Stanley

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Mouse liver Kupffer cells were induced to proliferate and form discrete colonies of mononuclear phagocytes in vitro. These colony-forming cells from the liver are similar to other mononuclear phagocyte colony-forming cells in that they require a colony-stimulating factor present in medium conditioned by L cells for proliferation in vitro. Cells in the colonies were phagocytic and had IgG receptors on the membrane. For this class of colony-forming cells, the D0 value to gamma irradiation in vitro was 108 rads.

Original languageEnglish (US)
Pages (from-to)103-109
Number of pages7
JournalExperimental Cell Research
Issue number1
StatePublished - Jun 1979

ASJC Scopus subject areas

  • Cell Biology


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