Clinical Implications of Guanine Nucleotide–Binding Proteins as Receptor–Effector Couplers

Jeffrey S. Flier, Lisa H. Underhill, Allen M. Spiegel, Peter Gierschik, Michael A. Levine, Robert W. Downs

Research output: Contribution to journalReview articlepeer-review

80 Scopus citations


IT has long been known that some cellular proteins bind guanine nucleotides such as guanosine tri-phosphate (GTP) with high affinity. These binding proteins are called G proteins and have been linked to such critical intracellular functions as protein synthesis.1 In the past decade three new G proteins have been discovered that reside in the plasma membrane and transmit information from the outside to the inside of the cell. Two of these new G proteins form part of the adenylate cyclase system, a membrane-bound enzyme complex found in virtually every cell, and the third G protein is found in the disk.

Original languageEnglish (US)
Pages (from-to)26-33
Number of pages8
JournalNew England Journal of Medicine
Issue number1
StatePublished - Jan 3 1985
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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