Clinical Implications and Management Strategies for Left Atrial Appendage Leaks

Anu Sahore; Domenico G. Della Rocca; Alisara Anannab; Sanghamitra Mohanty; Krishna Akella; Ghulam Murtaza; Chintan Trivedi; Carola Gianni; Qiong Chen; Mohamed Bassiouny; Ashkan Ahmadian-Tehrani; Bryan Macdonald; Amin Al-Ahmad; Nicola Tarantino; Donatello Cirone; Rodney P. Horton; Jorge Romero; Dhanunjaya Lakkireddy; Luigi Di Biase; Andrea Natale

doi:10.1016/j.ccep.2019.11.010

Clinical Implications and Management Strategies for Left Atrial Appendage Leaks

Anu Sahore, Domenico G. Della Rocca, Alisara Anannab, Sanghamitra Mohanty, Krishna Akella, Ghulam Murtaza, Chintan Trivedi, Carola Gianni, Qiong Chen, Mohamed Bassiouny, Ashkan Ahmadian-Tehrani, Bryan Macdonald, Amin Al-Ahmad, Nicola Tarantino, Donatello Cirone, Rodney P. Horton, Jorge Romero, Dhanunjaya Lakkireddy, Luigi Di Biase, Andrea Natale

Medicine

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Left atrial appendage (LAA) is the dominant source of systemic thromboembolic (TE) events in patients with nonvalvular atrial fibrillation (AF). In patients with significant bleeding risk, various LAA exclusion strategies have been developed as an alternative to pharmacologic TE prophylaxis. Nevertheless, in a relatively small percentage of patients, incomplete LAA closure can be documented, either at the time of procedure or during follow-up. This persistent patency can potentially jeopardize an effective stroke prophylaxis. Hereby, we report an update on the current clinical implications of LAA leaks and how to manage them.

Original language	English (US)
Pages (from-to)	89-96
Number of pages	8
Journal	Cardiac Electrophysiology Clinics
Volume	12
Issue number	1
DOIs	https://doi.org/10.1016/j.ccep.2019.11.010
State	Published - Mar 2020

Keywords

Amulet
Lariat
Leak
Left atrial appendage
Outcome
Stroke
Transient ischemic attach
Watchman

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

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10.1016/j.ccep.2019.11.010

Cite this

Sahore, A., Della Rocca, D. G., Anannab, A., Mohanty, S., Akella, K., Murtaza, G., Trivedi, C., Gianni, C., Chen, Q., Bassiouny, M., Ahmadian-Tehrani, A., Macdonald, B., Al-Ahmad, A., Tarantino, N., Cirone, D., Horton, R. P., Romero, J., Lakkireddy, D., Di Biase, L., & Natale, A. (2020). Clinical Implications and Management Strategies for Left Atrial Appendage Leaks. Cardiac Electrophysiology Clinics, 12(1), 89-96. https://doi.org/10.1016/j.ccep.2019.11.010

Sahore, A, Della Rocca, DG, Anannab, A, Mohanty, S, Akella, K, Murtaza, G, Trivedi, C, Gianni, C, Chen, Q, Bassiouny, M, Ahmadian-Tehrani, A, Macdonald, B, Al-Ahmad, A, Tarantino, N, Cirone, D, Horton, RP, Romero, J, Lakkireddy, D, Di Biase, L & Natale, A 2020, 'Clinical Implications and Management Strategies for Left Atrial Appendage Leaks', Cardiac Electrophysiology Clinics, vol. 12, no. 1, pp. 89-96. https://doi.org/10.1016/j.ccep.2019.11.010

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title = "Clinical Implications and Management Strategies for Left Atrial Appendage Leaks",

abstract = "Left atrial appendage (LAA) is the dominant source of systemic thromboembolic (TE) events in patients with nonvalvular atrial fibrillation (AF). In patients with significant bleeding risk, various LAA exclusion strategies have been developed as an alternative to pharmacologic TE prophylaxis. Nevertheless, in a relatively small percentage of patients, incomplete LAA closure can be documented, either at the time of procedure or during follow-up. This persistent patency can potentially jeopardize an effective stroke prophylaxis. Hereby, we report an update on the current clinical implications of LAA leaks and how to manage them.",

keywords = "Amulet, Lariat, Leak, Left atrial appendage, Outcome, Stroke, Transient ischemic attach, Watchman",

author = "Anu Sahore and {Della Rocca}, {Domenico G.} and Alisara Anannab and Sanghamitra Mohanty and Krishna Akella and Ghulam Murtaza and Chintan Trivedi and Carola Gianni and Qiong Chen and Mohamed Bassiouny and Ashkan Ahmadian-Tehrani and Bryan Macdonald and Amin Al-Ahmad and Nicola Tarantino and Donatello Cirone and Horton, {Rodney P.} and Jorge Romero and Dhanunjaya Lakkireddy and {Di Biase}, Luigi and Andrea Natale",

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doi = "10.1016/j.ccep.2019.11.010",

language = "English (US)",

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AU - Sahore, Anu

AU - Della Rocca, Domenico G.

AU - Anannab, Alisara

AU - Mohanty, Sanghamitra

AU - Akella, Krishna

AU - Murtaza, Ghulam

AU - Trivedi, Chintan

AU - Gianni, Carola

AU - Chen, Qiong

AU - Bassiouny, Mohamed

AU - Ahmadian-Tehrani, Ashkan

AU - Macdonald, Bryan

AU - Al-Ahmad, Amin

AU - Tarantino, Nicola

AU - Cirone, Donatello

AU - Horton, Rodney P.

AU - Romero, Jorge

AU - Lakkireddy, Dhanunjaya

AU - Di Biase, Luigi

AU - Natale, Andrea

PY - 2020/3

Y1 - 2020/3

N2 - Left atrial appendage (LAA) is the dominant source of systemic thromboembolic (TE) events in patients with nonvalvular atrial fibrillation (AF). In patients with significant bleeding risk, various LAA exclusion strategies have been developed as an alternative to pharmacologic TE prophylaxis. Nevertheless, in a relatively small percentage of patients, incomplete LAA closure can be documented, either at the time of procedure or during follow-up. This persistent patency can potentially jeopardize an effective stroke prophylaxis. Hereby, we report an update on the current clinical implications of LAA leaks and how to manage them.

AB - Left atrial appendage (LAA) is the dominant source of systemic thromboembolic (TE) events in patients with nonvalvular atrial fibrillation (AF). In patients with significant bleeding risk, various LAA exclusion strategies have been developed as an alternative to pharmacologic TE prophylaxis. Nevertheless, in a relatively small percentage of patients, incomplete LAA closure can be documented, either at the time of procedure or during follow-up. This persistent patency can potentially jeopardize an effective stroke prophylaxis. Hereby, we report an update on the current clinical implications of LAA leaks and how to manage them.

KW - Amulet

KW - Lariat

KW - Leak

KW - Left atrial appendage

KW - Outcome

KW - Stroke

KW - Transient ischemic attach

KW - Watchman

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JO - Cardiac Electrophysiology Clinics

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ER -

Clinical Implications and Management Strategies for Left Atrial Appendage Leaks

Abstract

Keywords

ASJC Scopus subject areas

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