Clinical considerations for vascularized composite allotransplantation of the eye

Edward H. Davidson; Eric W. Wang; Jenny Y. Yu; Juan C. Fernandez-Miranda; Dawn J. Wang; Yang Li; Maxine Miller; Wesley N. Sivak; Debra Bourne; Hongkun Wang; Mario G. Solari; Joel S. Schuman; Kia M. Washington

doi:10.1097/SCS.0000000000002985

Clinical considerations for vascularized composite allotransplantation of the eye

Edward H. Davidson, Eric W. Wang, Jenny Y. Yu, Juan C. Fernandez-Miranda, Dawn J. Wang, Yang Li, Maxine Miller, Wesley N. Sivak, Debra Bourne, Hongkun Wang, Mario G. Solari, Joel S. Schuman, Kia M. Washington

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Vascularized composite allotransplantation represents a potential shift in approaches to reconstruction of complex defects resulting from congenital differences as well as trauma and other acquired pathology. Given the highly specialized function of the eye and its unique anatomical components, vascularized composite allotransplantation of the eye is an appealing method for restoration, replacement, and reconstruction of the nonfunctioning eye. Herein, we describe conventional treatments for eye restoration and their shortcomings as well as recent research and events that have brought eye transplantation closer to a potential clinical reality. In this article, we outline some potential considerations in patient selection, donor facial tissue procurement, eye tissue implantation, surgical procedure, and potential for functional outcomes.

Original language	English (US)
Pages (from-to)	1622-1628
Number of pages	7
Journal	Journal of Craniofacial Surgery
Volume	27
Issue number	7
DOIs	https://doi.org/10.1097/SCS.0000000000002985
State	Published - 2016
Externally published	Yes

Keywords

Composite tissue allotransplantation
Eye transplant
Face transplant
Reconstructive transplantation
Vascularised composite allotransplantation

ASJC Scopus subject areas

Surgery
Otorhinolaryngology

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10.1097/SCS.0000000000002985

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Davidson, E. H., Wang, E. W., Yu, J. Y., Fernandez-Miranda, J. C., Wang, D. J., Li, Y., Miller, M., Sivak, W. N., Bourne, D., Wang, H., Solari, M. G., Schuman, J. S., & Washington, K. M. (2016). Clinical considerations for vascularized composite allotransplantation of the eye. Journal of Craniofacial Surgery, 27(7), 1622-1628. https://doi.org/10.1097/SCS.0000000000002985

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title = "Clinical considerations for vascularized composite allotransplantation of the eye",

abstract = "Vascularized composite allotransplantation represents a potential shift in approaches to reconstruction of complex defects resulting from congenital differences as well as trauma and other acquired pathology. Given the highly specialized function of the eye and its unique anatomical components, vascularized composite allotransplantation of the eye is an appealing method for restoration, replacement, and reconstruction of the nonfunctioning eye. Herein, we describe conventional treatments for eye restoration and their shortcomings as well as recent research and events that have brought eye transplantation closer to a potential clinical reality. In this article, we outline some potential considerations in patient selection, donor facial tissue procurement, eye tissue implantation, surgical procedure, and potential for functional outcomes.",

keywords = "Composite tissue allotransplantation, Eye transplant, Face transplant, Reconstructive transplantation, Vascularised composite allotransplantation",

author = "Davidson, {Edward H.} and Wang, {Eric W.} and Yu, {Jenny Y.} and Fernandez-Miranda, {Juan C.} and Wang, {Dawn J.} and Yang Li and Maxine Miller and Sivak, {Wesley N.} and Debra Bourne and Hongkun Wang and Solari, {Mario G.} and Schuman, {Joel S.} and Washington, {Kia M.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2016 by Mutaz B. Habal, MD.",

year = "2016",

doi = "10.1097/SCS.0000000000002985",

language = "English (US)",

volume = "27",

pages = "1622--1628",

journal = "Journal of Craniofacial Surgery",

issn = "1049-2275",

publisher = "Lippincott Williams and Wilkins",

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T1 - Clinical considerations for vascularized composite allotransplantation of the eye

AU - Davidson, Edward H.

AU - Wang, Eric W.

AU - Yu, Jenny Y.

AU - Fernandez-Miranda, Juan C.

AU - Wang, Dawn J.

AU - Li, Yang

AU - Miller, Maxine

AU - Sivak, Wesley N.

AU - Bourne, Debra

AU - Wang, Hongkun

AU - Solari, Mario G.

AU - Schuman, Joel S.

AU - Washington, Kia M.

PY - 2016

Y1 - 2016

N2 - Vascularized composite allotransplantation represents a potential shift in approaches to reconstruction of complex defects resulting from congenital differences as well as trauma and other acquired pathology. Given the highly specialized function of the eye and its unique anatomical components, vascularized composite allotransplantation of the eye is an appealing method for restoration, replacement, and reconstruction of the nonfunctioning eye. Herein, we describe conventional treatments for eye restoration and their shortcomings as well as recent research and events that have brought eye transplantation closer to a potential clinical reality. In this article, we outline some potential considerations in patient selection, donor facial tissue procurement, eye tissue implantation, surgical procedure, and potential for functional outcomes.

AB - Vascularized composite allotransplantation represents a potential shift in approaches to reconstruction of complex defects resulting from congenital differences as well as trauma and other acquired pathology. Given the highly specialized function of the eye and its unique anatomical components, vascularized composite allotransplantation of the eye is an appealing method for restoration, replacement, and reconstruction of the nonfunctioning eye. Herein, we describe conventional treatments for eye restoration and their shortcomings as well as recent research and events that have brought eye transplantation closer to a potential clinical reality. In this article, we outline some potential considerations in patient selection, donor facial tissue procurement, eye tissue implantation, surgical procedure, and potential for functional outcomes.

KW - Composite tissue allotransplantation

KW - Eye transplant

KW - Face transplant

KW - Reconstructive transplantation

KW - Vascularised composite allotransplantation

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Clinical considerations for vascularized composite allotransplantation of the eye

Abstract

Keywords

ASJC Scopus subject areas

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