TY - JOUR
T1 - Circulating vitamin D correlates with serum antimüllerian hormone levels in late-reproductive-aged women
T2 - Women's Interagency HIV Study
AU - Merhi, Zaher O.
AU - Seifer, David B.
AU - Weedon, Jeremy
AU - Adeyemi, Oluwatoyin
AU - Holman, Susan
AU - Anastos, Kathryn
AU - Golub, Elizabeth T.
AU - Young, Mary
AU - Karim, Roksana
AU - Greenblatt, Ruth
AU - Minkoff, Howard
N1 - Funding Information:
Data in this manuscript were collected by the Women's Interagency HIV Study (WIHS) Collaborative Study Group with centers (Principal Investigators) at New York City/Bronx Consortium (Kathryn Anastos); Brooklyn, New York (Howard Minkoff); Washington, DC, Metropolitan Consortium (Mary Young); The Connie Wofsy Study Consortium of Northern California (Ruth Greenblatt); Los Angeles County/Southern California Consortium (Alexandra Levine); Chicago Consortium (Mardge Cohen); and the Data Coordinating Center (Stephen Gange). The WIHS is funded by grants ( UO1-AI-35004, UO1-AI-31834, UO1-AI-34994, UO1-AI-34989, UO1-AI-34993, and UO1-AI-42590 ) from the National Institute of Allergy and Infectious Diseases and by a grant ( UO1-HD-32632 ) from the Eunice Kennedy Shriver National Institute of Child Health and Human Development . The study is cofunded by the National Cancer Institute, the National Institute on Drug Abuse, and the National Institute on Deafness and Other Communication Disorders. Funding is also provided by the National Center for Research Resources (University of California, San Francisco–Clinical and Translational Science Institute grant UL1 RR024131 ). The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health.
Funding Information:
D.B.S. receives royalties related to the use of müllerian-inhibiting substance for predicting ovarian response in women with infertility. O.A. receives funding to her institution from the National Institutes of Health (NIH) and from Merck . S.H. receives funding to herself and to her institution from NIH . K.A. receives funding to her institution from NIH. E.T.G. receives funding to her institution from NIH. M.Y. receives funding to her institution from NIH. R.G. receives funding to herself and to her institution from NIH. H.M. receives funding to his institution from NIH. Z.O.M. has nothing to disclose. J.W. has nothing to disclose. R.K. has nothing to disclose.
PY - 2012/7
Y1 - 2012/7
N2 - Objective: To study the correlation between circulating 25-hydroxyvitamin D (25OH-D) levels and serum antimüllerian hormone (AMH) in women enrolled in the Women's Interagency HIV Study. Design: Cross-sectional study. Setting: None. Patient(s): All premenopausal women (n = 388) with regular menstrual cycles were included and subdivided into three groups: group 1 with age <35 years (n = 128), group 2 with age 35-39 years (n = 119), and group 3 with age ≥40 years (n = 141). Intervention(s): Serum for 25OH-D, AMH, fasting glucose and insulin, and creatinine levels. Main Outcome Measure(s): Correlation between 25OH-D and AMH before and after adjusting for HIV status, body mass index, race, smoking, illicit drug use, glucose and insulin levels, estimated glomerular filtration rate, and geographic site of participation. Result(s): After adjusting for all covariates, the regression slope in all participants for total 25OH-D predicting log 10AMH for 25-year-olds (youngest participant) was -0.001 (SE = 0.008); and for 45-year-olds (oldest participant) the corresponding slope was +0.011 (SE = 0.005). Fasting insulin level was negatively correlated with serum AMH. The regression slope for the correlation between 25OH-D and AMH in group 1 was +0.002 (SE = 0.006); in group 2 was +0.006 (SE = 0.005); and in group 3 was +0.011 (SE = 0.005). There was no association between HIV and AMH. Conclusion(s): A novel relationship is reported between circulating 25OH-D and AMH in women aged ≥40 years, suggesting that 25OH-D deficiency might be associated with lower ovarian reserve in late-reproductive-aged women.
AB - Objective: To study the correlation between circulating 25-hydroxyvitamin D (25OH-D) levels and serum antimüllerian hormone (AMH) in women enrolled in the Women's Interagency HIV Study. Design: Cross-sectional study. Setting: None. Patient(s): All premenopausal women (n = 388) with regular menstrual cycles were included and subdivided into three groups: group 1 with age <35 years (n = 128), group 2 with age 35-39 years (n = 119), and group 3 with age ≥40 years (n = 141). Intervention(s): Serum for 25OH-D, AMH, fasting glucose and insulin, and creatinine levels. Main Outcome Measure(s): Correlation between 25OH-D and AMH before and after adjusting for HIV status, body mass index, race, smoking, illicit drug use, glucose and insulin levels, estimated glomerular filtration rate, and geographic site of participation. Result(s): After adjusting for all covariates, the regression slope in all participants for total 25OH-D predicting log 10AMH for 25-year-olds (youngest participant) was -0.001 (SE = 0.008); and for 45-year-olds (oldest participant) the corresponding slope was +0.011 (SE = 0.005). Fasting insulin level was negatively correlated with serum AMH. The regression slope for the correlation between 25OH-D and AMH in group 1 was +0.002 (SE = 0.006); in group 2 was +0.006 (SE = 0.005); and in group 3 was +0.011 (SE = 0.005). There was no association between HIV and AMH. Conclusion(s): A novel relationship is reported between circulating 25OH-D and AMH in women aged ≥40 years, suggesting that 25OH-D deficiency might be associated with lower ovarian reserve in late-reproductive-aged women.
KW - HIV
KW - Vitamin D
KW - antimüllerian hormone
KW - insulin resistance
KW - müllerian-inhibiting substance
KW - obesity
KW - ovarian reserve
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U2 - 10.1016/j.fertnstert.2012.03.029
DO - 10.1016/j.fertnstert.2012.03.029
M3 - Article
C2 - 22494925
AN - SCOPUS:84862978184
SN - 0015-0282
VL - 98
SP - 228
EP - 234
JO - Fertility and sterility
JF - Fertility and sterility
IS - 1
ER -
