Circulating miRNAs and miRNA shuttles as biomarkers: Perspective trajectories of healthy and unhealthy aging

Fabiola Olivieri, Miriam Capri, Massimiliano Bonafè, Cristina Morsiani, Hwa Jin Jung, Liana Spazzafumo, Jose Viña, Yousin Suh

Research output: Contribution to journalReview articlepeer-review

83 Scopus citations


Human aging is a lifelong process characterized by a continuous trade-off between pro-and anti-inflammatory responses, where the best-adapted and/or remodeled genetic/epigenetic profile may develop a longevity phenotype. Centenarians and their offspring represent such a phenotype and their comparison to patients with age-related diseases (ARDs) is expected to maximize the chance to unravel the genetic makeup that better associates with healthy aging trajectories. Seemingly, such comparison is expected to allow the discovery of new biomarkers of longevity together with risk factor for the most common ARDs. MicroRNAs (miRNAs) and their shuttles (extracellular vesicles in particular) are currently conceived as those endowed with the strongest ability to provide information about the trajectories of healthy and unhealthy aging. We review the available data on miRNAs in aging and underpin the evidence suggesting that circulating miRNAs (and cognate shuttles), especially those involved in the regulation of inflammation (inflamma-miRs) may constitute biomarkers capable of reliably depicting healthy and unhealthy aging trajectories.

Original languageEnglish (US)
Pages (from-to)162-170
Number of pages9
JournalMechanisms of Ageing and Development
StatePublished - Jul 2017


  • Aging trajectories
  • Centenarians
  • Circulating microRNAs
  • Offspring of centenarians
  • miR-21-5p

ASJC Scopus subject areas

  • Aging
  • Developmental Biology


Dive into the research topics of 'Circulating miRNAs and miRNA shuttles as biomarkers: Perspective trajectories of healthy and unhealthy aging'. Together they form a unique fingerprint.

Cite this