TY - JOUR
T1 - Circadian control of the immune system
AU - Scheiermann, Christoph
AU - Kunisaki, Yuya
AU - Frenette, Paul S.
N1 - Funding Information:
Our work was supported by grants from the US National Institutes of Health (R01 HL097700, DK056638, HL097819, HL116340 and HL069438) to P.S.F., from the German Academic Exchange Service (DAAD) to C.S. and from the Japan Society for the Promotion of Science to Y.K.
PY - 2013/3
Y1 - 2013/3
N2 - Circadian rhythms, which have long been known to play crucial roles in physiology, are emerging as important regulators of specific immune functions. Circadian oscillations of immune mediators coincide with the activity of the immune system, possibly allowing the host to anticipate and handle microbial threats more efficiently. These oscillations may also help to promote tissue recovery and the clearance of potentially harmful cellular elements from the circulation. This Review summarizes the current knowledge of circadian rhythms in the immune system and provides an outlook on potential future implications.
AB - Circadian rhythms, which have long been known to play crucial roles in physiology, are emerging as important regulators of specific immune functions. Circadian oscillations of immune mediators coincide with the activity of the immune system, possibly allowing the host to anticipate and handle microbial threats more efficiently. These oscillations may also help to promote tissue recovery and the clearance of potentially harmful cellular elements from the circulation. This Review summarizes the current knowledge of circadian rhythms in the immune system and provides an outlook on potential future implications.
UR - http://www.scopus.com/inward/record.url?scp=84875443859&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875443859&partnerID=8YFLogxK
U2 - 10.1038/nri3386
DO - 10.1038/nri3386
M3 - Review article
C2 - 23391992
AN - SCOPUS:84875443859
SN - 1474-1733
VL - 13
SP - 190
EP - 198
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 3
ER -