TY - JOUR
T1 - Cigarette smoking, incident coronary heart disease, and coronary artery calcification in black adults
T2 - The jackson heart study
AU - Oshunbade, Adebamike A.
AU - Kassahun-Yimer, Wondwosen
AU - Valle, Karen A.
AU - Hamid, Arsalan
AU - Kipchumba, Rodney K.
AU - Kamimura, Daisuke
AU - Clark, Donald
AU - White, Wendy B.
AU - Defilippis, Andrew P.
AU - Blaha, Michael J.
AU - Benjamin, Emelia J.
AU - O’brien, Emily C.
AU - Mentz, Robert J.
AU - Rodriguez, Carlos J.
AU - Fox, Ervin R.
AU - Butler, Javed
AU - Keith, Rachel J.
AU - Bhatnagar, Aruni
AU - Robertson, Rose Marie
AU - Correa, Adolfo
AU - Hall, Michael E.
N1 - Funding Information:
Sources of Funding The Jackson Heart Study is supported and conducted in collaboration with Jackson State University (HHSN268201800013I), Tougaloo College (HHSN268201800014I), the Mississippi State Department of Health (HHSN268201800015I) and the University of Mississippi Medical Center (HHSN268201800010I, HHSN268201800011I and HHSN268201800012I) contracts from the National Heart, Lung, and Blood Institute and the National Institute for Minority Health and Health Disparities. Dr Hall has also received support from the National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 1K08DK099415-01A1, National Institutes of Health/National Institute of General Medical Sciences P20GM104357 and National Institutes of Health/National Institute of General Medical Sciences 5U54GM115428. Dr Benjamin was funded by the American Heart Association, 18SFRN34110082 and 2U54HL120163. The views expressed in this article are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the US Department of Health and Human Services.
Funding Information:
The Jackson Heart Study is supported and conducted in collaboration with Jackson State University (HHSN268201800013I), Tougaloo College (HHSN268201800014I), the Mississippi State Department of Health (HHSN268201800015I) and the University of Mississippi Medical Center (HHSN268201800010I, HHSN268201800011I and HHSN268201800012I) contracts from the National Heart, Lung, and Blood Institute and the National Institute for Minority Health and Health Disparities. Dr Hall has also received support from the National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 1K08DK099415-01A1, National Institutes of Health/National Institute of General Medical Sciences P20GM104357 and National Institutes of Health/National Institute of General Medical Sciences 5U54GM115428. Dr Benjamin was funded by the American Heart Association, 18SFRN34110082 and 2U54HL120163. The views expressed in this article are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the US Department of Health and Human Services.
Funding Information:
Dr Benjamin serves as an uncompensated member for the MyHeartLab Steering Committee. The MyHeartLab Study is a principal investigator– initiated study from the University of California San Francisco: principal investigator, Jeffrey Olgin, MD, through a research grant to University of California San Francisco from Samsung. The remaining authors have no disclosures to report.
Publisher Copyright:
© 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.
PY - 2021
Y1 - 2021
N2 - BACKGROUND: Although Black adults are more likely to die from coronary heart disease (CHD) compared with White adults, few studies have examined the relationship between cigarette smoking and CHD risk among Black adults. We evaluated the relationship between cigarette smoking, incident CHD, and coronary artery calcification in the JHS (Jackson Heart Study). METHODS AND RESULTS: We classified JHS participants without a history of CHD (n=4432) by self-reported baseline smoking status into current, former (smoked at least 400 cigarettes/life) or never smokers at baseline (2000–2004). We further classified current smokers by smoking intensity (number of cigarettes smoked per day [1–19 or ≥20]) and followed for incident CHD (through 2016). Hazard ratios (HR) for incident CHD for each smoking group compared with never smokers were estimated with adjusted Cox proportional hazard regression models. At baseline, there were 548 (12.4%) current, 782 (17.6%) former, and 3102 (70%) never smokers. During follow-up (median, 13.8 years), 254 participants developed CHD. After risk factor adjust-ment, CHD risk was significantly higher in current smokers compared with never smokers (HR, 2.11; 95% CI, 1.39–3.18); the difference between former smokers and never smokers (HR, 1.37; 95% CI, 1.0–1.90) did not achieve statistical significance. Among current smokers, we did not observe a dose-response effect for CHD risk. Additionally, in multivariable logistic regression models with a subset of our analytic cohort, current smokers had greater odds of coronary artery calcification score >0 compared with never smokers (odds ratio, 2.63; 95% CI, 1.88–3.68). CONCLUSIONS: In a large prospective cohort of Black adults, current smoking was associated with a >2-fold increased risk of CHD over a median follow-up of greater than a decade.
AB - BACKGROUND: Although Black adults are more likely to die from coronary heart disease (CHD) compared with White adults, few studies have examined the relationship between cigarette smoking and CHD risk among Black adults. We evaluated the relationship between cigarette smoking, incident CHD, and coronary artery calcification in the JHS (Jackson Heart Study). METHODS AND RESULTS: We classified JHS participants without a history of CHD (n=4432) by self-reported baseline smoking status into current, former (smoked at least 400 cigarettes/life) or never smokers at baseline (2000–2004). We further classified current smokers by smoking intensity (number of cigarettes smoked per day [1–19 or ≥20]) and followed for incident CHD (through 2016). Hazard ratios (HR) for incident CHD for each smoking group compared with never smokers were estimated with adjusted Cox proportional hazard regression models. At baseline, there were 548 (12.4%) current, 782 (17.6%) former, and 3102 (70%) never smokers. During follow-up (median, 13.8 years), 254 participants developed CHD. After risk factor adjust-ment, CHD risk was significantly higher in current smokers compared with never smokers (HR, 2.11; 95% CI, 1.39–3.18); the difference between former smokers and never smokers (HR, 1.37; 95% CI, 1.0–1.90) did not achieve statistical significance. Among current smokers, we did not observe a dose-response effect for CHD risk. Additionally, in multivariable logistic regression models with a subset of our analytic cohort, current smokers had greater odds of coronary artery calcification score >0 compared with never smokers (odds ratio, 2.63; 95% CI, 1.88–3.68). CONCLUSIONS: In a large prospective cohort of Black adults, current smoking was associated with a >2-fold increased risk of CHD over a median follow-up of greater than a decade.
KW - Black adults
KW - Cigarette smoking
KW - Coronary artery calcification
KW - Coronary heart disease
KW - Jackson Heart Study
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UR - http://www.scopus.com/inward/citedby.url?scp=85104022274&partnerID=8YFLogxK
U2 - 10.1161/JAHA.120.017320
DO - 10.1161/JAHA.120.017320
M3 - Article
C2 - 33754833
AN - SCOPUS:85104022274
SN - 2047-9980
VL - 10
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 7
M1 - e017320
ER -