Chronic tympanic membrane perforation in an animal model

Nader Emami, Melvin D. Schloss, Sam J. Daniel

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Objective: The aim of this study was to revalidate and reproduce a chronic tympanic membrane perforation animal model. Study design: Prospective, animal study. Methods: Eight female chinchillas underwent bilateral thermal myringotomy. The edges of the perforation were folded inward using microflaps. The perforations were followed over time to monitor the course of closure. Results: Two animals were excluded from the study because of ear infection. None of the other tympanic membrane perforations remained open. The closing time varied from 4 to 6 weeks. Conclusions: Our findings demonstrate that the thermal myringotomy combined with infolding technique is not a reliable and consistent method to create a chronic tympanic membrane perforation. The closing time is shorter than expected and varies among the study subjects. There is a clear need for developing a reliable chronic tympanic membrane perforation model.

Original languageEnglish (US)
Pages (from-to)1250-1252
Number of pages3
JournalInternational journal of pediatric otorhinolaryngology
Issue number8
StatePublished - Aug 2014
Externally publishedYes


  • Animal model
  • Chronic
  • Tympanic membrane perforation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Otorhinolaryngology


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