Choroidal thickness profiles in myopic eyes of young adults in the correction of myopia evaluation trial cohort

Elise Harb, Leslie Hyman, Jane Gwiazda, Wendy Marsh-Tootle, Qinghua Zhang, Wei Hou, Thomas T. Norton, Katherine Weise, Keri Dirkes, Linda M. Zangwill, Li Deng, Kenneth Grice, Christine Fortunato, Cara Weber, Alexandra Beale, David Kern, Sally Bittinger, Debanjali Ghosh, Rosemarie Smith, Rosanna PacellaM. Cristina Leske, Mohamed Hussein, Li Ming Dong, Melissa Fazzari, Lynette Dias, Rachel Harrison, Wen Zhu, Elinor Schoenfeld, Ying Wang, Ahmed Yassin, Elissa Schnall, Cristi Rau, Jennifer Thomas, Marcela Wasserman, Yi Ju Chen, Sakeena Ahmed, Leanne Merill, Lauretta Passanant, Maria Rodriguez, Allison Schmertz, Ann Park, Phyllis Neuschwender, Geeta Veeraraghavan, Angela Santomarco, Laura Sisti, Lydia Seib, Donald Everett, Marcela Frazier, Catherine Baldwin, Carey Dillard, Kristine Becker, James Raley, Angela Rawden, Nicholas Harris, Trana Mars, Robert Rutstein, Daniel Kurtz, Erik Weissberg, Bruce Moore, Robert Owens, Sheila Martin, Joanne Bolden, Justin Smith, Benny Jaramillo, Stacy Hamlett, Laura Vasilakos, Sarah Gladstone, Chris Owens, Patricia Kowalski, Jennifer Hazelwood, Ruth Manny, Connie Crossnoe, Karen Fern, Heather Anderson, Sheila Deatherage, Charles Dudonis, Sally Henry, Jennifer McLeod, Mamie Batres, Julio Quiralte, Giselle Garza, Gabynely Solis, Joan Do, Andy Ketcham, Mitchell Scheiman, Kathleen Zinzer, Karen Pollack, Timothy Lancaster, Theresa Elliott, Mark Bernhardt, Daniel Ferrara, Jeff Miles, Scott Wilkins, Renee Wilkins, Jennifer Nicole Lynch, Dawn D'Antonio, Lindsey Lear, Sandy Dang, Charles Sporer, Mary Jameson, Abby Grossman, Mariel Torres, Heather Jones, Melissa Madigan-Carr, Theresa Sanogo, Joann Bailey, Robert Hardy, Argye Hillis, Donald Mutti, Richard Stone, Carol Taylor

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


Purpose To examine the relationship of choroidal thickness with axial length (AL) and myopia in young adult eyes in the ethnically diverse Correction of Myopia Evaluation Trial (COMET) cohort. Design Cross-sectional, multicenter study. Methods In addition to measures of myopia by cycloplegic autorefraction and AL by A-scan ultrasonography, participants underwent optical coherence tomography imaging of the choroid in both eyes at their last visit (14 years after baseline). Using digital calipers, 2 independent readers measured choroidal thickness in the right eye (left eye if poor quality; n = 37) at 7 locations: fovea and 750, 1500, and 2250 μm nasal (N) and temporal (T) to the fovea. Results Choroidal thickness measurements were available from 294 of 346 (85%) imaged participants (mean age: 24.3 ± 1.4 years; 44.9% male) with mean myopia of -5.3 ± 2.0 diopters and mean AL of 25.5 ± 1.0 mm. Overall, choroidal thickness varied by location (P <.0001) and was thickest at the fovea (273.8 ± 70.9 μm) and thinnest nasally (N2250, 191.5 ± 69.3 μm). Multivariable analyses showed significantly thinner choroids in eyes with more myopia and longer AL at all locations except T2250 (P ≤.001) and presence of peripapillary crescent at all locations except T1500 and T2250 (P ≤.0001). Choroidal thickness varied by ethnicity at N2250 (P <.0001), with Asians having the thinnest and African Americans the thickest choroids. Conclusion Choroids are thinner in longer, more myopic young adult eyes. The thinning was most prominent nasally and in eyes with a crescent. In the furthest nasal location, ethnicity was associated with choroidal thickness. The findings suggest that choroidal thickness should be evaluated, especially in the nasal regions where myopic degenerations are most commonly seen clinically.

Original languageEnglish (US)
Pages (from-to)62-71.e2
JournalAmerican journal of ophthalmology
Issue number1
StatePublished - Jul 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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