Chickpea Intoxication

L. G. Costa; Michael Aschner

doi:10.1016/B978-0-12-385157-4.00255-4

Chickpea Intoxication

L. G. Costa, Michael Aschner

Molecular Pharmacology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Consumption of chickpeas, the seeds of Lathyrus sativus, can lead to the development of a neurological disease known as lathyrism, characterized by spastic weakness of the legs. The disease, known for more than 2000 years and once diffused worldwide, is now restricted to certain areas of Asia and Africa. Though its exact mechanism is still obscure, a prevailing hypothesis is that it may be due to the presence of large amounts of an excitatory amino acid (. β-. N-oxalylamino-. l-alanine) in chickpeas, which is toxic to nerve cells and produces some of the symptoms seen in lathyrism when administered to animals.

Original language	English (US)
Title of host publication	Encyclopedia of the Neurological Sciences
Publisher	Elsevier Inc.
Number of pages	1
ISBN (Electronic)	9780123851574
ISBN (Print)	9780123851581
DOIs	https://doi.org/10.1016/B978-0-12-385157-4.00255-4
State	Published - Jan 1 2014

Keywords

Chickpea
Grass pea
Lathyrism
Lathyrus sativus
Neuronal death
Nitriles
Spasticity
β-N-oxalylamino-l-alanine (BOAA)

ASJC Scopus subject areas

Medicine(all)

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10.1016/B978-0-12-385157-4.00255-4

Cite this

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abstract = "Consumption of chickpeas, the seeds of Lathyrus sativus, can lead to the development of a neurological disease known as lathyrism, characterized by spastic weakness of the legs. The disease, known for more than 2000 years and once diffused worldwide, is now restricted to certain areas of Asia and Africa. Though its exact mechanism is still obscure, a prevailing hypothesis is that it may be due to the presence of large amounts of an excitatory amino acid (. β-. N-oxalylamino-. l-alanine) in chickpeas, which is toxic to nerve cells and produces some of the symptoms seen in lathyrism when administered to animals.",

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AU - Aschner, Michael

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N2 - Consumption of chickpeas, the seeds of Lathyrus sativus, can lead to the development of a neurological disease known as lathyrism, characterized by spastic weakness of the legs. The disease, known for more than 2000 years and once diffused worldwide, is now restricted to certain areas of Asia and Africa. Though its exact mechanism is still obscure, a prevailing hypothesis is that it may be due to the presence of large amounts of an excitatory amino acid (. β-. N-oxalylamino-. l-alanine) in chickpeas, which is toxic to nerve cells and produces some of the symptoms seen in lathyrism when administered to animals.

AB - Consumption of chickpeas, the seeds of Lathyrus sativus, can lead to the development of a neurological disease known as lathyrism, characterized by spastic weakness of the legs. The disease, known for more than 2000 years and once diffused worldwide, is now restricted to certain areas of Asia and Africa. Though its exact mechanism is still obscure, a prevailing hypothesis is that it may be due to the presence of large amounts of an excitatory amino acid (. β-. N-oxalylamino-. l-alanine) in chickpeas, which is toxic to nerve cells and produces some of the symptoms seen in lathyrism when administered to animals.

KW - Chickpea

KW - Grass pea

KW - Lathyrism

KW - Lathyrus sativus

KW - Neuronal death

KW - Nitriles

KW - Spasticity

KW - β-N-oxalylamino-l-alanine (BOAA)

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PB - Elsevier Inc.

ER -

Chickpea Intoxication

Abstract

Keywords

ASJC Scopus subject areas

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