Chelate Mediated Transfer of Iron from Transferrin to Desferrioxamine

Simeon Pollack, Philip Aisen, Fred D. Lasky, Grace Vanderhoff

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


SUMMARY. Desferrioxamine, widely used for the treatment of iron overload in Cooley's anaemia, binds iron so tightly that it should quantitatively remove iron from transferrin. Studies conducted in vivo and in vitro, however, have failed to demonstrate significant depletion of transferrin‐bound iron by a stoichiometric excess of desferrioxamine. However, low molecular weight chelating agents, capable of forming ternary complexes with transferrin and ferric iron, can promote a rapid transfer of iron from transferrin to desferrioxamine. A possible mechanism for this facilitated exchange is offered.

Original languageEnglish (US)
Pages (from-to)231-235
Number of pages5
JournalBritish Journal of Haematology
Issue number2
StatePublished - Oct 1976

ASJC Scopus subject areas

  • Hematology


Dive into the research topics of 'Chelate Mediated Transfer of Iron from Transferrin to Desferrioxamine'. Together they form a unique fingerprint.

Cite this