Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI)

Ariana M. Stickel; Wassim Tarraf; Kevin A. González; Vladamir Ivanovic; Alejandra Morlett Paredes; Donglin Zeng; Jianwen Cai; Carmen R. Isasi; Robert Kaplan; Richard B. Lipton; Martha Daviglus; Fernando D. Testai; Melissa Lamar; Linda C. Gallo; Gregory A. Talavera; Marc D. Gellman; Alberto R. Ramos; Hector M. González; Charles DeCarli

doi:10.1016/j.neurobiolaging.2023.02.007

Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI)

Ariana M. Stickel, Wassim Tarraf, Kevin A. González, Vladamir Ivanovic, Alejandra Morlett Paredes, Donglin Zeng, Jianwen Cai, Carmen R. Isasi, Robert Kaplan, Richard B. Lipton, Martha Daviglus, Fernando D. Testai, Melissa Lamar, Linda C. Gallo, Gregory A. Talavera, Marc D. Gellman, Alberto R. Ramos, Hector M. González, Charles DeCarli

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Hispanic/Latino adults are a growing segment of the older U.S. population yet are underrepresented in brain aging research. We aimed to characterize brain aging among diverse Hispanic/Latino individuals. Hispanic/Latino individuals (unweighted n = 2273 ages 35–85 years; 56% female) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) population-based study underwent magnetic resonance imaging (MRI) as part of the SOL- Investigation of Neurocognitive Aging MRI (SOL-INCA-MRI) ancillary study (2018–2022). We performed linear regressions to calculate age associations with brain volumes for each outcome (total (global) brain, hippocampal, lateral ventricle, total white matter hyperintensity (WMH), individual cortical lobar, and total cortical gray matter) and tested modification by sex. Older age was associated with smaller gray matter volumes and larger lateral ventricle and WMH volumes. Age-related differences in global brain volumes and gray matter volumes in specific regions (i.e., the hippocampus and temporal and occipital lobes) were less pronounced among women. Our findings warrant further investigation into sex-specific mechanisms of brain aging using longitudinal studies.

Original language	English (US)
Pages (from-to)	58-66
Number of pages	9
Journal	Neurobiology of Aging
Volume	126
DOIs	https://doi.org/10.1016/j.neurobiolaging.2023.02.007
State	Published - Jun 2023

Keywords

Aging
Brain
Brain Volumes
Hispanics
Latinos
White Matter Hyperintensities

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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Stickel, A. M., Tarraf, W., González, K. A., Ivanovic, V., Morlett Paredes, A., Zeng, D., Cai, J., Isasi, C. R., Kaplan, R., Lipton, R. B., Daviglus, M., Testai, F. D., Lamar, M., Gallo, L. C., Talavera, G. A., Gellman, M. D., Ramos, A. R., González, H. M., & DeCarli, C. (2023). Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI). Neurobiology of Aging, 126, 58-66. https://doi.org/10.1016/j.neurobiolaging.2023.02.007

Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI). / Stickel, Ariana M.; Tarraf, Wassim; González, Kevin A. et al.
In: Neurobiology of Aging, Vol. 126, 06.2023, p. 58-66.

Research output: Contribution to journal › Article › peer-review

Stickel, AM, Tarraf, W, González, KA, Ivanovic, V, Morlett Paredes, A, Zeng, D, Cai, J, Isasi, CR , Kaplan, R , Lipton, RB, Daviglus, M, Testai, FD, Lamar, M, Gallo, LC, Talavera, GA, Gellman, MD, Ramos, AR, González, HM & DeCarli, C 2023, 'Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI)', Neurobiology of Aging, vol. 126, pp. 58-66. https://doi.org/10.1016/j.neurobiolaging.2023.02.007

Stickel AM, Tarraf W, González KA, Ivanovic V, Morlett Paredes A, Zeng D et al. Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI). Neurobiology of Aging. 2023 Jun;126:58-66. doi: 10.1016/j.neurobiolaging.2023.02.007

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abstract = "Hispanic/Latino adults are a growing segment of the older U.S. population yet are underrepresented in brain aging research. We aimed to characterize brain aging among diverse Hispanic/Latino individuals. Hispanic/Latino individuals (unweighted n = 2273 ages 35–85 years; 56% female) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) population-based study underwent magnetic resonance imaging (MRI) as part of the SOL- Investigation of Neurocognitive Aging MRI (SOL-INCA-MRI) ancillary study (2018–2022). We performed linear regressions to calculate age associations with brain volumes for each outcome (total (global) brain, hippocampal, lateral ventricle, total white matter hyperintensity (WMH), individual cortical lobar, and total cortical gray matter) and tested modification by sex. Older age was associated with smaller gray matter volumes and larger lateral ventricle and WMH volumes. Age-related differences in global brain volumes and gray matter volumes in specific regions (i.e., the hippocampus and temporal and occipital lobes) were less pronounced among women. Our findings warrant further investigation into sex-specific mechanisms of brain aging using longitudinal studies.",

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author = "Stickel, {Ariana M.} and Wassim Tarraf and Gonz{\'a}lez, {Kevin A.} and Vladamir Ivanovic and {Morlett Paredes}, Alejandra and Donglin Zeng and Jianwen Cai and Isasi, {Carmen R.} and Robert Kaplan and Lipton, {Richard B.} and Martha Daviglus and Testai, {Fernando D.} and Melissa Lamar and Gallo, {Linda C.} and Talavera, {Gregory A.} and Gellman, {Marc D.} and Ramos, {Alberto R.} and Gonz{\'a}lez, {Hector M.} and Charles DeCarli",

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year = "2023",

month = jun,

doi = "10.1016/j.neurobiolaging.2023.02.007",

language = "English (US)",

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AU - Stickel, Ariana M.

AU - Tarraf, Wassim

AU - González, Kevin A.

AU - Ivanovic, Vladamir

AU - Morlett Paredes, Alejandra

AU - Zeng, Donglin

AU - Cai, Jianwen

AU - Isasi, Carmen R.

AU - Kaplan, Robert

AU - Lipton, Richard B.

AU - Daviglus, Martha

AU - Testai, Fernando D.

AU - Lamar, Melissa

AU - Gallo, Linda C.

AU - Talavera, Gregory A.

AU - Gellman, Marc D.

AU - Ramos, Alberto R.

AU - González, Hector M.

AU - DeCarli, Charles

PY - 2023/6

Y1 - 2023/6

N2 - Hispanic/Latino adults are a growing segment of the older U.S. population yet are underrepresented in brain aging research. We aimed to characterize brain aging among diverse Hispanic/Latino individuals. Hispanic/Latino individuals (unweighted n = 2273 ages 35–85 years; 56% female) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) population-based study underwent magnetic resonance imaging (MRI) as part of the SOL- Investigation of Neurocognitive Aging MRI (SOL-INCA-MRI) ancillary study (2018–2022). We performed linear regressions to calculate age associations with brain volumes for each outcome (total (global) brain, hippocampal, lateral ventricle, total white matter hyperintensity (WMH), individual cortical lobar, and total cortical gray matter) and tested modification by sex. Older age was associated with smaller gray matter volumes and larger lateral ventricle and WMH volumes. Age-related differences in global brain volumes and gray matter volumes in specific regions (i.e., the hippocampus and temporal and occipital lobes) were less pronounced among women. Our findings warrant further investigation into sex-specific mechanisms of brain aging using longitudinal studies.

AB - Hispanic/Latino adults are a growing segment of the older U.S. population yet are underrepresented in brain aging research. We aimed to characterize brain aging among diverse Hispanic/Latino individuals. Hispanic/Latino individuals (unweighted n = 2273 ages 35–85 years; 56% female) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) population-based study underwent magnetic resonance imaging (MRI) as part of the SOL- Investigation of Neurocognitive Aging MRI (SOL-INCA-MRI) ancillary study (2018–2022). We performed linear regressions to calculate age associations with brain volumes for each outcome (total (global) brain, hippocampal, lateral ventricle, total white matter hyperintensity (WMH), individual cortical lobar, and total cortical gray matter) and tested modification by sex. Older age was associated with smaller gray matter volumes and larger lateral ventricle and WMH volumes. Age-related differences in global brain volumes and gray matter volumes in specific regions (i.e., the hippocampus and temporal and occipital lobes) were less pronounced among women. Our findings warrant further investigation into sex-specific mechanisms of brain aging using longitudinal studies.

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Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI)

Abstract

Keywords

ASJC Scopus subject areas

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