TY - JOUR
T1 - Characterization of human papillomavirus type 120
T2 - A novel betapapillomavirus with tropism for multiple anatomical niches
AU - Bottalico, Danielle
AU - Chen, Zigui
AU - Kocjan, Boštjan J.
AU - Seme, Katja
AU - Poljak, Mario
AU - Burk, Robert D.
PY - 2012/8/1
Y1 - 2012/8/1
N2 - Recent studies indicate that human papillomaviruses (HPVs) from the genera Betapapillomavirus and Gammapapillomavirus are abundant in the human oral cavity. We report the cloning and characterization of a 7304 bp HPV120 genome from the oral cavity that is related most closely to HPV23 (L1 ORF, 83.7 % similarity), clustering it in the genus Betapapillomavirus (β-PV). HPV120 contains five early and two late genes, but no E5 ORF. HPV120 was detected from heterogeneous human biological niches, including the oral cavity, eyebrow hairs, anal canal and penile, vulvar and perianal warts. Characterization of the clinical spectrum of HPV120 infections indicates a broader spectrum of epithelial tropism than appreciated previously for HPV types from the genus β-PV.
AB - Recent studies indicate that human papillomaviruses (HPVs) from the genera Betapapillomavirus and Gammapapillomavirus are abundant in the human oral cavity. We report the cloning and characterization of a 7304 bp HPV120 genome from the oral cavity that is related most closely to HPV23 (L1 ORF, 83.7 % similarity), clustering it in the genus Betapapillomavirus (β-PV). HPV120 contains five early and two late genes, but no E5 ORF. HPV120 was detected from heterogeneous human biological niches, including the oral cavity, eyebrow hairs, anal canal and penile, vulvar and perianal warts. Characterization of the clinical spectrum of HPV120 infections indicates a broader spectrum of epithelial tropism than appreciated previously for HPV types from the genus β-PV.
UR - http://www.scopus.com/inward/record.url?scp=84864070836&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864070836&partnerID=8YFLogxK
U2 - 10.1099/vir.0.041897-0
DO - 10.1099/vir.0.041897-0
M3 - Article
C2 - 22552941
AN - SCOPUS:84864070836
SN - 0022-1317
VL - 93
SP - 1774
EP - 1779
JO - Journal of General Virology
JF - Journal of General Virology
IS - 8
ER -