Chaperone-mediated autophagy: Dice's 'wild' idea about lysosomal selectivity

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations


A little over 1 year ago, we lost a bright scientist and a dear colleague who, in his younger years, proposed the 'heretical' idea that lysosomes could selectively degrade cytosolic proteins. That scientist was J. Fred Dice, and his lifetime's discovery was the degradative pathway that we now know as chaperone-mediated autophagy.

Original languageEnglish (US)
Pages (from-to)535-541
Number of pages7
JournalNature Reviews Molecular Cell Biology
Issue number8
StatePublished - Aug 2011

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


Dive into the research topics of 'Chaperone-mediated autophagy: Dice's 'wild' idea about lysosomal selectivity'. Together they form a unique fingerprint.

Cite this