Changes in gene position are accompanied by a change in time of replication

Roger E. Calza, Laurel A. Eckhardt, Thomas Delgiudice, Carl L. Schildkraut

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


The globin and immunoglobulin multigene families have been used to study the effect of chromosomal organization on the time of gene replication. Some of the genes are late-replicating, providing the first identification of late-replicating sequences that are not highly repetitive. One is a member of the mouse α-globin gene family, which consists of genes mapping to three different chromosomes. The other genes in this family replicate early during S. Our studies demonstrate that immunoglobulin gene rearrangements and rearrangements between these genes and the c-myc oncogene are accompanied by dramatic differences in their temporal order of replication. We conclude that a gene's position in the chromosome, rather than its sequence, determines the time of replication. We suggest that the differences in association with gene rearrangement result from changes in the proximity of the affected gene to sites that control the temporal order of replication during S.

Original languageEnglish (US)
Pages (from-to)689-696
Number of pages8
Issue number3
StatePublished - Mar 1984

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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