Chagas' disease and AIDS

Anil K. Vaidian, Louis M. Weiss, Herbert B. Tanowitz

Research output: Contribution to journalArticlepeer-review

91 Scopus citations


Chagas' disease caused by Trypanosoma cruzi is an opportunistic infection in the setting of HIV/AIDS. Some individuals with HIV and chronic T. cruzi infection may experience a reactivation, which is most commonly manifested by meningoencephalitis. A reactivation myocarditis is the second most common manifestation. These presentations may be difficult to distinguish from toxoplasmosis in individuals with HIV/AIDS. The overlap of HIV and Trypanosoma cruzi infection occurs not only in endemic areas but also in non-endemic areas of North America and Europe where the diagnosis may be even more difficult. The pathological features, diagnosis and the role of cytokines in the pathogenesis of the disease are discussed.

Original languageEnglish (US)
Article number2
JournalKinetoplastid Biology and Disease
StatePublished - May 13 2004

ASJC Scopus subject areas

  • Immunology and Microbiology(all)


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