Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma

Yu Fang; Xiaoxin Chen; Manisha Bajpai; Amit Verma; Kiron M. Das; Rhonda F. Souza; Katherine S. Garman; Claire L. Donohoe; Naoimh J. O'Farrell; John V. Reynolds; Katerina Dvorak

doi:10.1111/nyas.12249

Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma

Yu Fang
, Xiaoxin Chen
, Manisha Bajpai
, Amit Verma
, Kiron M. Das
, Rhonda F. Souza
, Katherine S. Garman
, Claire L. Donohoe
, Naoimh J. O'Farrell
, John V. Reynolds
, Katerina Dvorak

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

This paper presents commentaries on animal models used for Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) research; acid- and bile-induced chromosomal instability and clonal selection during the progression of BE to EAC; how the components of gastric refluxate, especially acid and bile salts, promote carcinogenesis in metaplastic BE; genome-wide changes in DNA methylation and transcription involved in BE carcinogenesis; the potential role of miRNA in the development of BE and EAC; the effect of inflammatory cytokines linked to obesity on the activation of cell-death pathways and cell survival in BE and esophageal cancer; and the role of autophagy in esophageal cancer development.

Original language	English (US)
Pages (from-to)	187-199
Number of pages	13
Journal	Annals of the New York Academy of Sciences
Volume	1300
Issue number	1
DOIs	https://doi.org/10.1111/nyas.12249
State	Published - Oct 2013
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Autophagy
Barrett's esophagus
DNA methylation
Esophageal adenocarcinoma
Obesity

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

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10.1111/nyas.12249

Cite this

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title = "Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma",

abstract = "This paper presents commentaries on animal models used for Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) research; acid- and bile-induced chromosomal instability and clonal selection during the progression of BE to EAC; how the components of gastric refluxate, especially acid and bile salts, promote carcinogenesis in metaplastic BE; genome-wide changes in DNA methylation and transcription involved in BE carcinogenesis; the potential role of miRNA in the development of BE and EAC; the effect of inflammatory cytokines linked to obesity on the activation of cell-death pathways and cell survival in BE and esophageal cancer; and the role of autophagy in esophageal cancer development.",

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author = "Yu Fang and Xiaoxin Chen and Manisha Bajpai and Amit Verma and Das, \{Kiron M.\} and Souza, \{Rhonda F.\} and Garman, \{Katherine S.\} and Donohoe, \{Claire L.\} and O'Farrell, \{Naoimh J.\} and Reynolds, \{John V.\} and Katerina Dvorak",

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AU - Fang, Yu

AU - Chen, Xiaoxin

AU - Bajpai, Manisha

AU - Verma, Amit

AU - Das, Kiron M.

AU - Souza, Rhonda F.

AU - Garman, Katherine S.

AU - Donohoe, Claire L.

AU - O'Farrell, Naoimh J.

AU - Reynolds, John V.

AU - Dvorak, Katerina

PY - 2013/10

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N2 - This paper presents commentaries on animal models used for Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) research; acid- and bile-induced chromosomal instability and clonal selection during the progression of BE to EAC; how the components of gastric refluxate, especially acid and bile salts, promote carcinogenesis in metaplastic BE; genome-wide changes in DNA methylation and transcription involved in BE carcinogenesis; the potential role of miRNA in the development of BE and EAC; the effect of inflammatory cytokines linked to obesity on the activation of cell-death pathways and cell survival in BE and esophageal cancer; and the role of autophagy in esophageal cancer development.

AB - This paper presents commentaries on animal models used for Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) research; acid- and bile-induced chromosomal instability and clonal selection during the progression of BE to EAC; how the components of gastric refluxate, especially acid and bile salts, promote carcinogenesis in metaplastic BE; genome-wide changes in DNA methylation and transcription involved in BE carcinogenesis; the potential role of miRNA in the development of BE and EAC; the effect of inflammatory cytokines linked to obesity on the activation of cell-death pathways and cell survival in BE and esophageal cancer; and the role of autophagy in esophageal cancer development.

KW - Autophagy

KW - Barrett's esophagus

KW - DNA methylation

KW - Esophageal adenocarcinoma

KW - Obesity

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UR - https://www.scopus.com/pages/publications/84885440265#tab=citedBy

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AN - SCOPUS:84885440265

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EP - 199

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

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Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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