@inbook{8013577f4ed544a88cc127bbd72a450f,
title = "Cell internalization SELEX: In vitro selection for molecules that internalize into cells",
abstract = "Aptamer technology allows for the selection of nucleic acids that can bind to and enter cells. By establishing conditions during the selection that eliminate cell-surface binders as well as non-internalizing RNAs, only extremely tightly bound aptamers or aptamers that have internalized are recovered. We describe a general scheme for selecting RNA molecules that are capable of internalizing into cells and discuss the factors that can affect a successful selection. Much like standard cell-surface selections, these types of selections should be possible independent of detailed knowledge of the cell surface.",
keywords = "Aptamer, Cell internalization, In vitro selection, SELEX, Targeted delivery",
author = "Amy Yan and Matthew Levy",
year = "2014",
doi = "10.1007/978-1-62703-730-3_18",
language = "English (US)",
isbn = "9781627037297",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "241--265",
booktitle = "Therapeutic Applications of Ribozymes and Riboswitches",
}