Ca2+-permeable AMPA receptors in synaptic plasticity and neuronal death

Siqiong June Liu, R. Suzanne Zukin

Research output: Contribution to journalReview articlepeer-review

436 Scopus citations


AMPA receptors mediate fast synaptic transmission at excitatory synapses in the CNS and are crucial during neuronal development, synaptic plasticity and structural remodeling. AMPA receptors lacking GluR2 subunits are permeable to Ca2+ and Zn2+. Ca2+ permeation through AMPA receptors is crucial in several forms of synaptic plasticity and cell death associated with neurological diseases and disorders. The subunit composition and Ca2+ permeability of AMPA receptors are not static, but they are dynamically remodeled in a cell- and synapse-specific manner during development and in response to neuronal activity, sensory experience and neuronal insults. Exciting new research shows that these changes arise not only because of regulated expression of the AMPA receptor subunit GluR2, but also as a consequence of RNA editing, receptor trafficking and dendritic protein synthesis. This article reviews new insights into the role of Ca2+-permeable AMPA receptors in neuronal function and survival.

Original languageEnglish (US)
Pages (from-to)126-134
Number of pages9
JournalTrends in Neurosciences
Issue number3
StatePublished - Mar 2007

ASJC Scopus subject areas

  • General Neuroscience


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