TY - JOUR
T1 - Case series
T2 - Hyponatremia associated with moderate exercise
AU - Zelingher, Julian
AU - Putterman, Chaim
AU - Ilan, Yaron
AU - Dann, Eldad J.
AU - Zveibil, Fabio
AU - Shvil, Yigal
AU - Galun, Eithan
N1 - Funding Information:
From the *Division of Internal Medicine and §Department of Pediatrics, Hadassah University Hospital-Ein Kerem, Jerusalem, Israel, the Vntensive Care Unit, Western Galilee Regianal Hospital, Nahariya, Israel, and the tDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York. Supported in part by the United Israel Appeal, Canada Branch. Submitted August 14, 1995, and accepted for publication in revised form September 13, 1995. Correspondence: Chaim Putterman, MD, Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461.
PY - 1996/2
Y1 - 1996/2
N2 - Exercise-induced hyponatremia is commonly believed to be associated only with extraordinary physical efforts, or particularly strenuous exercise. Hyponatremia complicating moderate exercise has not been described previously. The authors describe the characteristics of seven patients with life-threatening hyponatremia associated with mild to moderate exercise. All patients suffered from nausea, vomiting, agitation, and confusion, appearing during or after moderate physical activity. Grand real convulsions occurred in five of the patients. In laboratory results, hyponatremia was as low as 115 mEq/L, with a relatively high sodium concentration in the urine. High serum creatine kinase activity levels were found in most of the patients. All patients were discharged in good condition, without neurologic sequela. The authors conclude that hyponatremia is a possible complication of moderate exercise, and not only of endurance sports, and that exercise-induced hyponatremia can produce severe neurologic manifestations. The mechanism of the hyponatremia is unclear, but may be due to a hemodynamically inappropriate stimulus for antidiuretic hormone secretion.
AB - Exercise-induced hyponatremia is commonly believed to be associated only with extraordinary physical efforts, or particularly strenuous exercise. Hyponatremia complicating moderate exercise has not been described previously. The authors describe the characteristics of seven patients with life-threatening hyponatremia associated with mild to moderate exercise. All patients suffered from nausea, vomiting, agitation, and confusion, appearing during or after moderate physical activity. Grand real convulsions occurred in five of the patients. In laboratory results, hyponatremia was as low as 115 mEq/L, with a relatively high sodium concentration in the urine. High serum creatine kinase activity levels were found in most of the patients. All patients were discharged in good condition, without neurologic sequela. The authors conclude that hyponatremia is a possible complication of moderate exercise, and not only of endurance sports, and that exercise-induced hyponatremia can produce severe neurologic manifestations. The mechanism of the hyponatremia is unclear, but may be due to a hemodynamically inappropriate stimulus for antidiuretic hormone secretion.
KW - Exercise
KW - Hyponatremia
KW - Inappropriate antidiuretic hormone secretion
KW - Rhabdomyolysis
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U2 - 10.1097/00000441-199602000-00007
DO - 10.1097/00000441-199602000-00007
M3 - Article
C2 - 8615381
AN - SCOPUS:0030062722
SN - 0002-9629
VL - 311
SP - 86
EP - 91
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
IS - 2
ER -