Case-Control Study of Cervicovaginal β/γ–Human Papillomavirus Infection in Women With Human Immunodeficiency Virus and Its Relation to Incident Cervical Precancer

Howard D. Strickler; Mykhaylo Usyk; Isam Eldin Eltoum; Natalie Bachman; Nancy A. Hessol; Lisa Flowers; Lisa Rahangdale; Jessica M. Atrio; Catalina Ramirez; Howard Minkoff; Adaora A. Adimora; Igho Ofotokun; Marla J. Keller; Margaret Fischl; Sadeep Shrestha; Rodney Wright; Gypsyamber D’Souza; Lorraine Sanchez-Keeland; Xianhong Xie; Xiaonan Xue; Kathryn Anastos; L. Stewart Massad; Joel M. Palefsky; Robert D. Burk

doi:10.1093/infdis/jiae588

Case-Control Study of Cervicovaginal β/γ–Human Papillomavirus Infection in Women With Human Immunodeficiency Virus and Its Relation to Incident Cervical Precancer

Howard D. Strickler
, Mykhaylo Usyk
, Isam Eldin Eltoum
, Natalie Bachman
, Nancy A. Hessol
, Lisa Flowers
, Lisa Rahangdale
, Jessica M. Atrio
, Catalina Ramirez
, Howard Minkoff
, Adaora A. Adimora
, Igho Ofotokun
, Marla J. Keller
, Margaret Fischl
, Sadeep Shrestha
, Rodney Wright
, Gypsyamber D’Souza
, Lorraine Sanchez-Keeland
, Xianhong Xie
, Xiaonan Xue

Kathryn Anastos, L. Stewart Massad, Joel M. Palefsky, Robert D. Burk

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We studied cervicovaginal β/γ–human papillomavirus (HPV) and their relationship to cervical precancer in women with human immunodeficiency virus; having previously reported strong positive associations of β/γ-HPV with incident head and neck cancer in the general population. Case patients (n = 124) had cervical intraepithelial neoplasia (CIN) 3 or 2. Controls (n = 247) were individually matched 2:1 to case patients. Unexpectedly, multivariate analyses found strong inverse associations between β/γ-HPV and CIN-2/3 (odds ratio, 0.19 [95% confidence interval, .04–.86]; P = .03; P_trend < .01]). This is, to our knowledge, the first study of β/γ-HPV and cervical precancer. If confirmed, a strong inverse (protective) association would be of potential clinical and biologic relevance.

Original language	English (US)
Pages (from-to)	595-599
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	231
Issue number	3
DOIs	https://doi.org/10.1093/infdis/jiae588
State	Published - Mar 15 2025

Keywords

CIN-3
cervical precancer
human papillomavirus (HPV)
women with HIV (WWH)
β/γ-HPV

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jiae588

Cite this

Strickler, H. D., Usyk, M., Eltoum, I. E., Bachman, N., Hessol, N. A., Flowers, L., Rahangdale, L., Atrio, J. M., Ramirez, C., Minkoff, H., Adimora, A. A., Ofotokun, I., Keller, M. J., Fischl, M., Shrestha, S., Wright, R., D’Souza, G., Sanchez-Keeland, L., Xie, X., ... Burk, R. D. (2025). Case-Control Study of Cervicovaginal β/γ–Human Papillomavirus Infection in Women With Human Immunodeficiency Virus and Its Relation to Incident Cervical Precancer. Journal of Infectious Diseases, 231(3), 595-599. https://doi.org/10.1093/infdis/jiae588

Case-Control Study of Cervicovaginal β/γ–Human Papillomavirus Infection in Women With Human Immunodeficiency Virus and Its Relation to Incident Cervical Precancer. / Strickler, Howard D.; Usyk, Mykhaylo; Eltoum, Isam Eldin et al.
In: Journal of Infectious Diseases, Vol. 231, No. 3, 15.03.2025, p. 595-599.

Research output: Contribution to journal › Article › peer-review

Strickler, HD, Usyk, M, Eltoum, IE, Bachman, N, Hessol, NA, Flowers, L, Rahangdale, L, Atrio, JM, Ramirez, C, Minkoff, H, Adimora, AA, Ofotokun, I, Keller, MJ, Fischl, M, Shrestha, S, Wright, R, D’Souza, G, Sanchez-Keeland, L, Xie, X, Xue, X, Anastos, K, Massad, LS, Palefsky, JM & Burk, RD 2025, 'Case-Control Study of Cervicovaginal β/γ–Human Papillomavirus Infection in Women With Human Immunodeficiency Virus and Its Relation to Incident Cervical Precancer', Journal of Infectious Diseases, vol. 231, no. 3, pp. 595-599. https://doi.org/10.1093/infdis/jiae588

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abstract = "We studied cervicovaginal β/γ–human papillomavirus (HPV) and their relationship to cervical precancer in women with human immunodeficiency virus; having previously reported strong positive associations of β/γ-HPV with incident head and neck cancer in the general population. Case patients (n = 124) had cervical intraepithelial neoplasia (CIN) 3 or 2. Controls (n = 247) were individually matched 2:1 to case patients. Unexpectedly, multivariate analyses found strong inverse associations between β/γ-HPV and CIN-2/3 (odds ratio, 0.19 [95\% confidence interval, .04–.86]; P = .03; Ptrend < .01]). This is, to our knowledge, the first study of β/γ-HPV and cervical precancer. If confirmed, a strong inverse (protective) association would be of potential clinical and biologic relevance.",

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AU - Eltoum, Isam Eldin

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AU - Xie, Xianhong

AU - Xue, Xiaonan

AU - Anastos, Kathryn

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Case-Control Study of Cervicovaginal β/γ–Human Papillomavirus Infection in Women With Human Immunodeficiency Virus and Its Relation to Incident Cervical Precancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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